The present study was undertaken to evaluate the effect of Lactobacillus kefiri (PFT), a novel kefir product, on apoptosis of gastric cancer cells (AGS), breast cancer cells (4T1), and human peripheral blood mononuclear cells (PBMCs). Cells were cultured with PFT and apoptosis was determined by flow cytometry using 7-AAD dye and cytospin preparation. Mitochondrial dysfunction and expression of ...

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In order to cope efficiently with the dependability analysis of redundant systems with replicated units, a new, more compact fault-tree formalism, called Parametric Fault Tree (PFT), is defined. In a PFT formalism, replicated units are folded and indexed so that only one representative of the similar replicas is included in the model. From the PFT, a list of parametric cut sets can be derived, ...

BACKGROUND Among patients with obstructive lung disease, the correlation between clinical improvement and bronchodilator response is poor. Forced expiratory time (FET) may explain some discrepancy, but FET has received little attention. METHODS We analyzed change in FET during the 3 initial satisfactory flow-volume loops in 102 consecutive patients, 37 with normal spirometry and 65 with airfl...

Protein prenylation occurs in the protozoan that causes African sleeping sickness (Trypanosoma brucei), and the protein farnesyltransferase appears to be a good target for developing drugs. We have cloned the alpha- and beta-subunits of T. brucei protein farnesyltransferase (TB-PFT) using nucleic acid probes designed from partial amino acid sequences obtained from the enzyme purified from insec...

Cognitive impairment, termed chemobrain, is a common neurotoxicity associated with chemotherapy treatment, affecting an estimated 78% of patients. Prompted by the hypothesis that neuronal mitochondrial dysfunction underlies chemotherapy-induced cognitive impairment (CICI), we explored the efficacy of administering the small-molecule pifithrin (PFT)-μ, an inhibitor of mitochondrial p53 accumulat...

The United States Army administers fitness tests and collects height and weight data for soldiers and cadets in order to determine a measure of physical readiness. This study examined individual test results from the U.S. Army’s Physical Fitness Test (PFT) and respective Body Mass Index (BMI) to see if any association existed in male ROTC (Reserve Officer Training Corps.) cadets. If a correlati...

The reliability of wearable photoplethysmography (PPG) sensors to measure heart rate (HR) in hospitalized patients has only been demonstrated in adults. We evaluated the accuracy of HR monitoring with a personal fitness tracker (PFT) in children undergoing surgery. HR monitoring was performed using a wrist-worn PFT (Fitbit Charge HR) in 30 children (8.21 ± 3.09 years) undergoing laparoscopy (n ...

In a mobile cellular system quality of service to mobile terminals (MTs) is measured by the probability of new call blocking Pb, and the probability of forced termination, Pft. Since the available bandwidth in a cell is very limited, both Pb and Pft cannot be reduced or avoided simultaneously. Usually keeping the Pft below a designated level is accepted as the measure of quality of service. Adm...