Four native Papaver species of Iran, i. e. P. glaucum, P. tenuifolium, P. dubium and P. fugax, were collected from their natural habitat and subjected to HPLC analysis for determination of their morphine, codeine and thebaine content. P. dubium and R. glaucum contained all of the three mentioned narcotic alkaloids, while morphine was not found in P. fugax, and P. tenuifolium was free from codeine.

Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver som...

papaverfugax poiret population tarom was shown to contain one major alkaloid, mecamberine (0.4%), and six minor alkaloids, roemerine, pronuciferine, protopine, thebaine, nornuciferine and salutaridine. nornuciferine was detected for the first time in p. fugax

The research was conducted with the aim of examining alkaloids content twelve poppies (Papaver somniferum L.) cultivars registered in Turkey by correlation and path analysis relationships among capsule yield. field experiments were set up according to a randomized complete block design three replications 2017-18 2018-19 under semi-arid ecological conditions Isparta, Turkey. differences yields a...

It has been firmly established that humans excrete a small but steady amount of the isoquinoline alkaloid morphine in their urine. It is unclear whether it is of dietary or endogenous origin. There is no doubt that a simple isoquinoline alkaloid, tetrahydropapaveroline (THP), is found in human and rodent brain as well as in human urine. This suggests a potential biogenetic relationship between ...

There are three types of opiate alkaloids. First, the poppy alkaloids: morphine, codeine, thebaine, noscapine and papaverine; then, the semi-synthetic and synthetic derivatives used in therapy as antitussives and analgesics, such as pholcodine, ethylmorphine and dextromethorphan; at last narcotic compounds, diacetylmorphine (heroin) and opiates employed as substitutes in treatment of addiction:...

A 35-year-old male was referred because of eczema on the arms and lips that occurred episodically. He worked in a drug-manufacturing plant, and noticed that the episodes of eczema coincided with the production cycles of thebaine (CAS no. 115-37-7) and oripavine (CAS no. 467-04-9), but not with the production cycles of morphine (CAS no. 57-27-2) and noscapine (CAS no. 128-62-1). The eczema start...

T he world’s entire supply of opioid painkillers begins with the opium poppy (Papaver somniferum). Every year, about 100,000 ha of the crop is grown for its opiate compounds, which are extracted and converted into analgesics such as codeine and hydrocodone. Bioengineer Christina Smolke of Stanford University thinks it’s time for a new approach. Last year, she developed yeast that turns glucose ...