The wide range of variability of the reduction potential (E(0)) of blue-copper proteins has been the subject of a large number of studies in the past several years. In particular, a series of azurin mutants have been recently rationally designed tuning E(0) over a very broad range (700 mV) without significantly altering the redox-active site [Marshall et al., Nature, 2009, 462, 113]. This clear...

It is no surprise that the catalytic activity of electron-transport enzymes may be optimised at certain electrochemical potentials in ways that are analogous to observations of pH-rate optima. This property is observed clearly in experiments in which an enzyme is adsorbed on an electrode surface which can supply or receive electrons rapidly and in a highly controlled manner. In such a way, the ...

Affiliations: 1 Graz University of Technology Institute for Theoretical Computer Science Inffeldgasse 16b/I 8010 Graz, Austria 2 Max Planck Institute for Biological Cybernetics Spemannstrasse 38 72076 Tübingen, Germany 3 Imaging Science and Biomedical Engineering University of Manchester Manchester, United Kingdom Page 1 of 68 Articles in PresS. J Neurophysiol (December 26, 2007). doi:10.1152/j...

The fundamental understanding of molecule-surface reactions is of great importance to heterogeneous catalysis, motivating many theoretical and experimental studies. Even though much attention has been dedicated to the dissociative chemisorption of N2 on tungsten surfaces, none of the existing theoretical models has been able to quantitatively reproduce experimental reaction probabilities for th...

Corrosion resistance has become an important factor to consider in integrated computational materials engineering, yet generating science-based indicators of corrosion for hypothetical remains challenging. We explore the quantitative relations between work function and potential, taking a theoretical approach that considers relation these thermodynamic kinetically-determined variables. The is f...

Precise matching of energy supply with demand requires delicately balanced control of the enzymes involved in substrate metabolism. In response to a change in substrate supply, the nonlinear properties of metabolic control may induce complex dynamic behavior. Using confocal imaging of flavoprotein redox potential and mitochondrial membrane potential, we show that substrate deprivation leads to ...

The Redox Potential of DDT: An Environmental Perspective Anne Lewis1, Christopher Cramer2, and John Bumpus Department of Chemistry and the Environmental Sciences Program University of Northern Iowa Cedar Falls, Iowa 50614 Department of Chemistry University of Minnesota Minneapolis, Minnesota Due to their low water solubility, the reduction potentials of DDT and dicofol are difficult to determin...