Preclinical studies suggest that fasting prior to chemotherapy may be an effective strategy to protect patients against the adverse effects of chemo-toxicity. Fasting may also sensitize cancer cells to chemotherapy. It is further suggested that fasting may similarly augment the efficacy of oncolytic viral therapy. The primary mechanism mediating these beneficial effects is thought to relate to ...

Hypoglycemia is due to defects in the metabolic systems involved transition from fed fasting state or hormone control of these systems. In children, hypoglycemia considered a metabolic-endocrine emergency, because it may lead brain injury, permanent neurological sequelae and, rare cases, death. Symptoms are nonspecific, particularly infants and young children. Diagnosis based on laboratory inve...

background resistance exercise is recommended as a useful therapeutic tool for the treatment of type 2 diabetes (t2d); however, the frequency of studies is inadequate to establish the precise mechanisms of any association between them. objectives in this study, we aimed to assess the effect of three months of resistance training on tcf7l2 expression in pancreatic tissues, serum insulin and gluc...

Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand potential effects of Croton genus on several diseases. It has revealed that these terpenoid-rich species traditionally used treat gastrointestinal diseases, heal wounds, relieve pain a wide range therapeutic effects; however, those diabetes, as well their action mechanisms, not reviewed so fa...

conclusions it was concluded that the efficacy of tramadol and fluoxetine in males with premature ejaculation are the same and both are effective. both of these drugs are safe to treat premature ejaculation. results thirty-six subjects with the mean age of 44 ± 19.3 years underwent analysis. eighteen subjects were treated by fluoxetine and 18 by tramadol. the efficacy of treatment in the two gr...

glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (ms) and other autoimmune inflammatory cns disorders. n‑methyl‑d‑aspartate (nmda) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. current treatment approaches targeting glutamate exc...

goldfish carassius auratus were subjected to either formalin (250 ppm) or nacl (10 ppt), over a 0.5-h period followed by 24-h freshwater exposure. serum biochemistry was monitored before exposure (0), immediately after (0.5) plus 3 and 24 h after exposure. results showed that both formalin and nacl treatments caused rapid increase in cortisol with a peak at 3 h, which did not recover until 24 h...

Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability to inhibit lipoprotein lipase, Angptl4 stimulates intracellular adipocyte lip...