conclusions taken together, these data reveal that cellular protease of chicken liver cells allows the replication of high yields of h9n2 virus in the absence of trypsin and also cell death in the infected cells is due to necrosis. results the degree of viability was significantly reduced in infected hepatoma cells. observations of caspase activation and cell dna laddering in infected cells wer...

brucellosis is a zoonotic disease mostly transmitted to humans through consumption of unpasteurized dairy products and can lead to a systemic disease with any organ involvement. in this report, we describe a case of brucellosis-induced avascular necrosis of the hip. brucellosis was diagnosed through serological tests, and avascular necrosis of the femoral head was confirmed by pelvic mri. the p...

Previously we have developed a free boundary model for local thermal coagulation induced by laser light absorption when the tissue region affected directly by laser light is sufficiently small and heat diffusion into the surrounding tissue governs the necrosis growth. In the present paper surveying the obtained results we state the point of view on the necrosis formation under these conditions ...

In bone cutting, the tissue is exposed to necrosis due temperature elevation, which can significantly influence postoperative results in orthopaedic surgeries. This damage usually revealed through histological analysis show necrotic extent; however, this technique does not capture mechanical damage, essential for a full material integrity assessment. Here, with micro-mechanics, it demonstrated ...

A 3D Finite Element Method (FEM) model for directional removing of a tumor is presented in this paper. The proposed model shows a new method to control the direction of the temperature diffusion during the thermal ablation. We developed a directional probe with a curved cathode as heating source to remove the malignant cells and protect the surrounding healthy cells. With the use of the COMSOL ...

BACKGROUND Radiofrequency-generating energy devices have been used clinically in musculoskeletal procedures to provide hemostasis and capsular shrinkage (thermal capsulorrhaphy). However, the dose-effects are not well known. QUESTIONS/PURPOSES We therefore determined dosage effects of radiofrequency energy on bone, skin incisions, and joint capsule in sheep. METHODS Five mature sheep had si...

BACKGROUND Ultrasonic scalpel (UC) and monopolar electrocautery (ME) are common tools for soft tissue dissection. However, morphological data on the related tissue alteration are discordant. We developed an automatic device for standardized sample excision and compared quality and depth of morphological changes caused by UC and ME in a pig model. METHODS 100 tissue samples (5 × 3 cm) of the a...

Minimally invasive stereotactic tumor ablation is a viable option for the treatment of benign and malignant intracranial lesions. Although surgical excision constitutes first-line therapy for various brain pathologies, it can cause irreversible neurologic deficits. Additionally, many patients who may benefit from surgery do not qualify as surgical candidates due to multiple comorbidities. Recen...

The use of thermal energy-based systems to treat uterine fibroids has resulted in a plethora of devices that are less invasive and potentially as effective in reducing symptoms as traditional options such as myomectomy. Most thermal ablation devices involve hyperthermia (heating of tissue), which entails the conversion of an external electromagnetic or ultrasound waves into intracellular mechan...

warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. most patients develop this complication at the initiation of therapy. the complication is ‎usually associated with an underlying thrombophilia. here we describe a case of a 75 year old ‎patient who developed skin necrosis in her both breasts during warfarin treatment for a ‎deep vein thrombosi...