Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could scale batch safety reasons. Some examples included a Newman Kwart Rearrangement, Claisen rearrangement, hydroformylation, and thermal imidazole cyclization. Next, flow enable safe of hazardous chemistries manufacturing plant...

In order to find the susceptibility of the Claisen rearrangement and next proton shift reaction of ally) aryl etherto the substiment effects in pan position, the kinetic and the:rmodynamie parameters are calculated at The33 LTP level using 6-3110. b asis set. The calculated activation energies for the rearrangements and protonshift reactions are around 3133 kcaUmol and 52.16 kcal/mol, nap.. liv...

A Chan-Lam reaction has been used to prepare N-alkenyl-α,β-unsaturated nitrones, which undergo a subsequent thermal rearrangement to the corresponding tri- and tetrasubstituted pyridines. The optimization and scope of these transformations is discussed. Initial mechanistic experiments suggest a reaction pathway involving oxygen transfer followed by cyclization.

Dynamic surface rearrangement and thermal stability of N-functional groups on carbon nanotubes (CNTs), obtained by functionalization of pristine CNTs with NH(3), were studied by temperature-programmed XPS and MS: a link between the stability of the functional group and decomposition temperature have been established and a conversion into graphitic nitrogen was observed.

The Mo(CO)6-mediated photoinduced ring-opening reactions of adamantane isoxazolines involve novel rearrangement that provide enaminoketones as major products and b-hydroxy ketones as minor ones; in contrast, only b-hydroxy ketones and a,b-unsaturated ketones were obtained under thermal condition. 2006 Elsevier Ltd. All rights reserved. Table 1. Synthesis of substituted adamantane-isoxazolines 1a–d

A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position.