A series of new 2,3,5-triaryl-substituted oxazolium and thiazolium salts are readily prepared by a Tf(2)O-mediated intramolecular cyclisation and their use as precursors for the synthesis of novel oxazol-4-ylidene and thiazol-4-ylidene rhodium complexes has been developed.

A new benzothiazole-based chemosensor BTN (1-((Z)-(((E)-3-methylbenzo[d]thiazol-2(3H)-ylidene)hydrazono)methyl)naphthalen-2-ol) was synthesized for the detection of Cu2+. could detect Cu2+ with “off-on” fluorescent response from colorless to yellow irrespective presence other cations. Limit determined be 3.3 μM. Binding ratio and turned out a 1:1 analysis Job plot ESI-MS. Sensing feature by exp...

A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

We have designed and synthesized novel bis-thiazole derivative. A 4-[bis(thiazol-2-ylamino)methyl]phenol was efficiently prepared in 71% yield by the reaction of 2-aminothiazole with 4-hydroxybenzaldehyde ethanol for 24 h. The structure newly obtained compound characterized 1H, 13C NMR mass spectrometry. Bis-thiazole derivative exhibits high tyrosinase inhibitory activity an IC50 value 29.71 μM...

Asymmetric catalysis represents a very powerful tool for the synthesis of enantiopure compounds. In this context the main focus has been directed not only to the search for new efficient chiral catalysts, but also to the development of efficient pronucleophiles. This review highlights the utility and first examples of 1H-imidazol-4(5H)-ones and thiazol-4(5H)-ones as pronucleophiles in catalytic...

(pyrazol-3-yl)pyridmium group at the C-3' position as a combination of the pyridine moiety of ceftazidime2) and the pyrazole moiety of cefoselis3) to attain a synergic effect in activity. As we expected, those compoundsexhibited wellbalanced and broad spectrum of activity against Grampositive and Gram-negative bacteria. Of them, 7-[(Z)-2-(2aminol ,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3[(3...