A new series of heterocycles incorporating antipyrine moiety were synthesized via reactions of 4-aminoantipyrine 1 with carbon disulphide then alkylation and /or chloroacetic acid to produce dithiocarbamate and rhodanine 3, 4 and 9. Multi-component reaction (MCR) of 4-aminoantipyrine with carbon disulfide and DMAD afforded rhodanine 7. The interaction of 9 with diazonium salt, DMF-DMA, nitrous ...

A series of novel thiazolidinones have been synthesized by reaction of various Schiff bases of coumarin with thioglycolic acid. The reaction of 4-hydroxy coumarin with POCl3 yielded 4chloro coumarin 2 and 4-chloro-3, 4', 3', 4"-tercoumarin 2a. Compound 2 was reacted with pphenylene diamine to yield 4-[(4-aminophenyl)amino]-2H-chromen-2-one.Various Schiff bases of coumarin were synthesized by co...

A new generation of chroman bearing heterocyclic five membered ring such as 1,2,4-triazoles and thiazolidinones was designed and synthesized. New chroman based nucleus 5-(6-fluorochroman-2-yl)-4-aryl-4H-1,2,4-triazole-3-thiol and 6-fluorochroman-N-(4-oxo-2-arylthiazolidinin-3-yl) chroman-2-carboxamides were synthesized. Aryl triazole compounds 4a-4j were synthesized from 6-fluorochroman-2-carbo...

Several novel N substituted sulfapyridine derivatives were synthesized by condensation of 2-ChloroN-(4-(N-pyridin-2-ylsulfamoyl)phenyl) acetamide 2 with different amino acids, amines, malononitrile, or ammonium thiocyanate to yield the corresponding alkanoic acid derivatives 3a-f, acetamide derivatives 48, pyrrole derivatives 912, and thiazolidinone derivative 13. The newly synthesized compound...

Steroidal compounds in the roots of Asclepias tuberosa were investigated and 17alpha-hydroxyandrosta-4,6,15-trien-3-one 17-O-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside, termed ascandroside, was isolated from the CHCl3-soluble fraction. Among five doubly-linked cardenolide glycosides, two were identified as 3'-spiro-linked thiazolidinone (4) and S-oxythiazolidinone derivatives (5) o...

Esterification of p-bromo-m-cresol led to formation of 2-(4-bromo-3-methylphenoxy)acetate (1). 2-(4-Bromo-3-methyl phenoxy)acetohydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield N-(substituted benzylidiene)-2-(4-bromo-3-methyl phenoxy)acetamide(3a-c). Cyclization of compound (3a-c) with thioglycolic acid yielded 2-(4...

A series of novel bis-thiazolidinone derivatives 3(a-j) have been synthesized by the cyclization thiosemicarbazones 2(a-j) with chloroacetic acid and sodium acetate. The integrated heterocyclic compounds were featured chemical spectroscopic methods such as IR, 1H NMR 13C NMR. All screened for their antimicrobial activity against Gram-positive Gram-negative bacteria Staphylococcus Aureus, Bacill...