With the advent of rapid genome sequencing, the view of the human genome as a vast desert dotted with far-flung oases of functional genes has contended with a growing appreciation of the role of regulatory sequences in shaping gene expression. The fraction of the human genome’s noncoding component that can be considered functional remains to be established, but strewn across the seeming wastela...

The calculation of uncertainty for a measurement is an effort to set reasonable bounds for the measurement result according to standardized rules. Since every measurement produces only an estimate of the answer, the primary requisite of an uncertainty statement is to inform the reader of how sure the writer is that the answer is in a certain range. This report explains how we have implemented t...

Perhaps the most famous brain injury in history was a penetrating wound suffered by a rail road worker named Phineas Gage on September 13, 1848. Twelve years after his injury, on the 21st of May, 1860 Phineas Gage died of an epileptic seizure. In 1868 Dr. Harlow gave an outline of Gage's case history and first disclosed his remarkable personality change. One might think this report would assure...

BACKGROUND Cancer/testis antigens (CTAs) are expressed in several cancers and during normal adult male germ cell differentiation. Little is known about their role in fetal development of human germ cells. METHODS We examined expression of the CTAs MAGE-A1, GAGE and NY-ESO-1 in fetal gonads by single and double immunohistochemical staining. RESULTS We found that GAGE was expressed in the pri...

Strain gage rosettes are used often in engineering practice to determine strain states at specific points on a structure. Figure 1 illustrates three commonly used strain gage rosette configurations. Each of these configurations is designed with a specific task in mind. The far right rosette in Figure 1 is referred to as a tee rosette. Tee rosettes are two element rosettes and should only be use...

The purpose of this project is to set up a statistical process control (SPC) system in a high volume machining center to reduce the scrap rate and improve the manufacturing quality. The system is demonstrated on a machining center at Waters Corporation as part of a team internship project. This thesis focuses on the gage repeatability and reproducibility study (Gage R&R study) for the implement...

PURPOSE Previous biomechanical studies have estimated the strains of bone and bone substitutes using strain gages. However, applying strain gages to biological samples can be difficult, and data collection is limited to a small area under the strain gage. The purpose of this study was to compare digital image correlation (DIC) strain measurements to those obtained from strain gages in order to ...

Doppler radar data are increasingly used in rainfall-runoff synthesis studies, perhaps due to radar data availability, among other factors. However, the veracity of the radar data are often a topic of concern. In this paper, three Doppler radar outcomes developed by the United States National Weather Service at three radar sites are examined and compared to actual rain gage data for two separat...

Previous studies directed at identifying paclitaxel resistance genes in a paclitaxel-resistant subclone of the human ovarian cancer cell line SKOV-3 identified a novel cancer testis antigen, Taxol resistance-associated gene 3 (TRAG-3). Because investigation suggested that TRAG-3, located on chromosome Xq28, does not directly participate in the paclitaxel-resistant phenotype, it was hypothesized...

Barbara Gage, PhD, MPA, is Senior Vice President, Scientific Research and Evaluation, PAC Center for Research, and Fellow, Brookings Institution, Washington, DC. Leland, N. E., Crum, K., Phipps, S., Roberts, P., & Gage, B. (2015). Health Policy Perspectives—Advancing the value and quality of occupational therapy in health service delivery. American Journal of Occupational Therapy, 69, 690109001...