We have already shown that the in-vacuum gas-phase Meerwein reaction of (thio)acylium ions is general in nature and useful for class-selective screening of cyclic (thio)epoxides. Herein we report that this gas-phase reaction can also be performed efficiently at atmospheric pressure under both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) conditions. This alte...

Thermal decomposition of a mixture of the two stereoisomeric bis(2,5-dihydro-1,3,4-thiadiazoles) cisand trans-2, which was prepared by treatment of 2,2,4,4-tetramethylcyclobutane-1,3-dithione with excess of diazomethane in the presence of two equivalents of N-methylmaleimide, led to a mixture of three 1:2 cycloadducts of type 4. The structures of these thiocarbonyl methanide-adducts have been e...

This study tested the hypothesis that membrane-tethered type-1 matrix metalloproteinase (MT1-MMP)-induced proteolysis of T cell CD44 is important for defining the migration and function of autoreactive T cells, including diabetogenic, insulin-specific and K(d)-restricted IS-CD8(+) cells. To confirm the importance of MT1-MMP proteolysis of CD44 in type 1 diabetes (T1D), the anti-diabetic effects...

Poly (N-bromosuccinimide) (PNBS) as a mild, efficient, non-acidic, polymeric and heterogeneous catalyst was applied for simple conversion of epoxides into thiiranes by treatment with KSCN or (NH2)2CS at room temperature. Aliphatic and aromatic epoxides converted into their corresponding thiiranes under mild conditions. All reactions proceeded in short reaction times and afforded the correspondi...

A discharge-flow modulated molecular beam mass spectrometry technique has been used to determine the rate constant for reaction of ground state oxygen atoms with C2H4S in temperature range 220–950 K. The determined directly by monitoring an excess O and through competitive Br2. Weak, negative dependence is observed below 300 K, whereas positive above 380 K: k = 1.13 × 10–12 (T/298)2.18 exp(733/...