The response tomethimazole(l-methyl-2-mercaptoimidazol,MMl) therapy was evaluated in 18 patients with diffuse toxic goitre residing in an area of iodine deficiency(Tehran)and in 18 such patients residing in an area of iodine sufficiency(Boston) .Free T4 index(FT4I) decreased from 22.9± 4.8 to 4.9± 4.3 in Tehran and from 23.8± 5.2 to 17.0±4.1 in Boston, 4 weeks after administration of MMl 10 mg ...

INTRODUCTION Recombinant human thyroid-stimulating hormone(rhTSH) increases radioactive iodine uptake(RAIU) in selected populations, while lithium is used as an adjunct to radioactive iodine (RAI) therapy in Graves' disease with low RAIU. In this report, both drugs used in combination, overcame low iodine-131 uptake in a Graves' patient. CLINICAL CASE A 39-year old female with Graves' disease...

A useful correlation between maximum thyroid uptake and radioiodine urine levels at different times after exposure was developed in order to determine when the intervention with an adequate blocking agent might still be effective. In an animal model (dog), six different doses were administered in the range of 100-600 kBq. The best correlation was found between the 125I uptake after 48 h (T-48) ...

Oxygen deprivation during ischemic or hemorrhagic stroke results in ATP depletion, loss of ion homeostasis, membrane depolarization, and excitotoxicity. Pharmacologic restoration of cellular energy supply may offer a promising concept to reduce hypoxic cell injury. In this study, we investigated whether carbimazole, a thionamide used to treat hyperthyroidism, reduces neuronal cell damage in oxy...

introduction: recombinant human thyroid-stimulating hormone(rhtsh) increases radioactive iodine uptake(raiu) in selected populations, while lithium is used as an adjunct to radioactive iodine (rai) therapy in graves’ disease with low raiu. in this report, both drugs used in combination, overcame low iodine-131 uptake in a graves’ patient. clinical case: a 39-year old female with graves’ disease...

Background: Graves’ disease (GD) is an autoimmune disorder and the leading cause of hyperthyroidism. Antithyroid drugs (ATDs) are available treatment option. Agranulocytosis a rare but potentially fatal complication ATD in hyperthyroidism management. The study's objectives include clinical symptoms ATD-induced agranulocytosis Graves' illness difficulties care addition to radioactive iodine ther...

Sarcoidosis is a systemic granulomatous disease of unknown etiology. In most cases, mediastinal lymph nodes and lung parenchyma are involved. In addition, the eyes, skin, abdominal organs, central nervous system or the joints might be involved during the course of the disease. Sarcoidosis has been found to be related with other autoimmune diseases such as thyroiditis. In this report, we present...

Drug-induced autoimmunity provides a fascinating glimpse of the environment’s contribution to the development of anti-self reactivity. After a period of treatment, certain drugs induce, in a subset of individuals, clinical signs that are typically found only in autoimmune disorders. The clinical features of drug-induced autoimmunity are a reminder that genetic predisposition to self reactivity ...