Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...

In this study, we compared the effects of Calendula and Alpha ointment in the treatment of burn wounds and compare its results with silver sulfadiazine (SSD). Seventy-five male Sprague-Dawley rats were divided into five groups, and similar burn ulcers were produced on anterior surface of thigh of rats. The first group of rats no treatment was applied, base gel was applied topically to group II,...

BACKGROUND It has been shown that topical nanoliposomal formulations improve burn healing process. On the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption; there is not such data available for burn eschar. Present investigation studies permeation of clindamycin phosphate (CP) through burn eschar from l...

Objective-The objective of this study was to compare effects of olive oil and lime water combination with silver sulfadiazine in third-degree burn healing. Design-Randomized experimental study. Animals-Sixty-three adult male Bulb/C mice weighing25±5 gr. Procedures-The mice were anesthetized with an intraperitoneal injection of ketamine 10% and xylazine 2% combination and the t...

AIM The effect of Tualang honey on wound healing in bacterial contaminated full-thickness burn wounds was evaluated in 36 male Sprague Dawley rats. MATERIALS AND METHODS The rats were randomly divided into three groups (n = 12/group). Three full-thickness burn wounds were created on each rat. Each group of rats was inoculated with a different organism in the burn wounds: Group A was inoculate...

Berman, Sanford (Walter Reed Army Institute of Research, Washington, D. C.), Joseph P. Lowenthal, Marion E. Webster, Patricia L. Altieri, and Raymond B. Gochenour. Factors affecting the elaboration by Clostridium histolyticum of proteinases capable of debriding third degree burn eschars on guinea pigs. J. Bacteriol. 82:582-588. 1961.-A comparison of three strains of Clostridium histolyticum gro...

Wound healing is a complex and long lasting biochemical and biologic process. This study was conducted to investigate the influence of 1046-nm Pulsed High Intensity Nd: YAG Laser in the treatment of 3 rd degree experimental burn wound on rats. Twenty four clinical healthy male Sprague-Dawley (SD) rats with induced two full thickness burn wound measuring 6 cm 2 on the dorsal aspect, one wound ac...

antimicrobial therapy remains to be the most important method of wound infection treatment. systemically administered antimicrobials may not achieve therapeutic level in wound. on the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. burn eschar is a protei...

BACKGROUND Severe burns result in hypercatabolic state and concomitant muscle atrophy that persists for several months, thereby limiting patient recovery. However, the effects of burns on the corresponding spinal dermatome remain unknown. This study aimed to investigate whether burns induce apoptosis of spinal cord ventral horn motor neurons (VHMNs) and consequently cause skeletal muscle wastin...