J Neurol Stroke 2017, 6(4): 00206 Thrombolysis (PROACT) followed by the PROACT II [3] have laid the foundation for IA-thrombolysis. Recanalization in the range of 66%, complete Recanalization (Thrombolysis in Myocardial Infarction [TIMI] grade 3) in 19% and improved outcome with IA-thrombolysis made it a definite advantage over IV rt-PA. Despite higher recanalization rates, the relative unpredi...

CONTEXT Early administration of thrombolysis for acute myocardial infarction (AMI) may improve survival if safely and appropriately delivered. No systematic reviews that have comprehensively examined this topic exist in the literature. OBJECTIVE To perform a meta-analysis of randomized controlled trials of prehospital vs in-hospital thrombolysis for AMI measuring in-hospital mortality. DATA...

In concept, mechanical interventions are attractive options for treating acute myocardial infarction with or without preceding thrombolysis: rapid reperfusion of the infarct-related artery can be achieved in the vast majority of cases, and the underlying coronary lesion is treated at the same time. Various strategies have been extensively investigated. When performed in specialized centres, dir...

BACKGROUND AND PURPOSE In patients with ischemic stroke, randomized trials showed a better functional outcome after endovascular therapy with new-generation thrombectomy devices compared with medical treatment, including intravenous thrombolysis. However, effects on mortality and the generalizability of results to routine clinical practice are uncertain. METHODS In a prospective observational...

BACKGROUND AND PURPOSE Determine feasibility and safety of intravenous (IV) versus combined (IV-IA [intra-arterial]) thrombolysis guided by transcranial color-coded duplex sonography (TCCD). METHODS Thirty-three patients eligible for IV thrombolysis, within 3 hours of onset of symptoms, with occlusion in middle cerebral artery territory (TCCD monitoring, thrombolysis in brain ischemia [TIBI] ...

BACKGROUND thrombolysis for stroke has been licensed in the UK since 2007 and needs to be administered within 4.5 h. Given this time critical factor, the media may have an important role in public awareness. METHODS this review aimed to find out how stroke thrombolysis was reported in UK national and London local newspapers and how treatment risks and benefits were communicated. Newspapers pu...

BACKGROUND AND PURPOSE Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounted for by patient demographics, regional factors, and elements of stroke syste...

BACKGROUND AND PURPOSE Decreasing the time delay for thrombolysis, including intravenous thrombolysis (IVT) with tissue plasminogen activator and intra-arterial thrombectomy (IAT), is critical for decreasing the morbidity and mortality of patients experiencing acute stroke. We aimed to decrease the in-hospital delay for both IVT and IAT through a multidisciplinary approach that is feasible 24 h...

BACKGROUND AND PURPOSE The safety and efficacy of thrombolysis in cervical artery dissection (CAD) are controversial. The aim of this meta-analysis was to pool all individual patient data and provide a valid estimate of safety and outcome of thrombolysis in CAD. METHODS We performed a systematic literature search on intravenous and intra-arterial thrombolysis in CAD. We calculated the rates o...

BACKGROUND Dementia represents a potential challenge when thrombolysis is a treatment option. In this study, we assess the impact of dementia on the rate of intracerebral hemorrhage (ICH) and hospital mortality associated with acute ischemic stroke (AIS) in patients treated with thrombolysis. METHODS A cohort of patients with AIS was identified from the National Inpatient Sample database for ...