Antibodies that reacted with plasma membranes of human eye muscle but showed no binding to plasma membranes of human skeletal muscle were identified in serum of patients with Graves' ophthalmopathy. Rabbit antithyroglobulin serum at a dilution of 1 X 10(-3) to 20 X 10(-3) had no effect on the binding of these antibodies to eye muscle membrane antigens. There was no correlation between antihuman...

introduction: imatinib, a tyrosine kinase inhibitor which resulted in much improvement in the treatment of chronic myelogenous leukemia (cml), may adversely affect thyroid gland function. to date, assessment of thyroid function during imatinib therapy has limited to retrospective studies. the aim of this study was to evaluate the effects of imatinib on thyroid function in a prospective manner. ...

OBJECTIVE To investigate the prevalence of autoimmune thyroid disease in diabetic children in Northwest Iran. METHODS In a cross-sectional study from February 2006 to November 2007, serum levels of anti-thyroid peroxidase, and anti-thyroglobulin antibodies, and thyrotropin hormone were measured with ELISA method in 176 diabetic children (78 Male and 98 Female) at a mean age of 8.3 +/- 3.7 and...

During the individual development and exposure to infectious agents of organism, structural components thyroid gland can change significantly. In modern research, great importance is attached study mechanisms for maintaining morphological homeostasis ideas about its functional restructuring in response body's immune system various infections. The morpho-functional features newborn animals after...

Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases. Here we assess the relative importance of the fragments obtained from thyroglobulin by limited proteolysis with trypsin and compare by immunoblotting their reactivity to s...

Coexistence of differentiated thyroid cancer (DTC) and thyroid autoimmune diseases could represent a mere coincidence due to the frequent occurrence of autoimmunity, but there may also be a pathological and causative link between the two conditions. The coincidence of DTC with Hashimoto's disease has been variably reported at between 0.5 and 22.5% and of DTC with Graves' disease between 0 and 9...

Aim: To find out association of Serum Thyroid Stimulating Hormone (TSH) and Anti-Thyroid Antibodies (ATA) i.e., anti Tg-Ab & TPO-Ab with thyroid carcinoma in nodule patients presented Mayo Hospital Lahore. Study design: It was a comparative cross-sectional study. Methods: wasconducted Biochemistry Department Biomedical Sciences KEMU, Lahore from February 2018 to May 2019. Seventy were inclu...

When CD4+ CD25+ regulatory T cells are depleted or inactivated for the purpose of enhancing antitumor immunity, the risk of autoimmune disease may be significantly elevated because these regulatory T cells control both antitumor immunity and autoimmunity. To evaluate the relative benefit and risk of modulating CD4+ CD25+ regulatory T cells, we established a new test system to measure simultaneo...