INTRODUCTION Our objective was to determine the interrelationships of interleukin (IL)-6 receptor inhibition with haemoglobin, acute-phase reactants and iron metabolism markers (including hepcidin) in patients with rheumatoid arthritis (RA). METHODS Data of patients receiving tocilizumab or placebo in the MEASURE study were analysed. We investigated associations at baseline and during tociliz...

OBJECTIVE The aim of the present study was to investigate the relationship between iron, ferritin, transferrin, total iron binding capacity (TIBC), hemoglobin, mean corpuscular volume (MCV) mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) in children with ADHD. METHODS MethodsaaThe sample consisted of 48 ADHD children and sex and age matched control chil...

AIMS To investigate the clinical value and practice of reflective testing, a new term to describe the practice of adding on tests when reporting or clinically authorising results. METHODS A consultant medical biochemist collected over a calendar year (2001) copies of clinical biochemistry reports on samples to which he had added on either iron studies (iron, total iron binding capacity (TIBC)...

BACKGROUND Genetic variants of human transferrin (TF) have been described, but little is known about their functional differences. We studied iron status according to TF phenotype in a healthy Zimbabwean population and in subjects at risk of African iron overload. METHODS The study population consisted of 483 nondrinkers, 31 drinking spouse pairs, and 5 family pedigrees (n = 88) with index ca...

OBJECTIVES To determine whether blood cadmium concentration is elevated in iron-deficient infants. METHODS Blood cadmium and serum ferritin concentrations, serum iron/total iron-binding capacity (Fe/TIBC) and complete blood counts were measured in 31 iron deficient and 36 control infants, aged 6-24 months. All 31 iron-deficient infants received iron supplementation for 1-6 months. RESULTS B...

Introduction. Iron deficiency (ID) of varying severity is the most common and rather serious extra-gynecological complication adenomyosis resulting from meno/metrorrhagia intensity, up to abnormal uterine bleeding requiring surgical hemostasis. Taking into account chronic course disease, complexity radical therapy as well a systemic effect ID also particularly affecting reproductive system, an ...

Abstract Background and Aims Chronic kidney disease (CKD) is widely linked to chronic inflammation, with a higher incidence in the advanced stages of disease. Recognition systemic inflammation may be useful for prompt diagnosis management various CKD related disorders open door towards development application anti-inflammatory strategy treatments. This case-control cross-sectional study investi...