The ageing of society is undoubtedly a success, but also challenge modern medicine. Postmenopausal women struggle with many health problems, and their treatment recommended so far often associated side effects such as the increased risk hormone-dependent tumours or thromboembolism. purpose this article to discuss relatively new drug called tibolone against currently treatment. unique mechanism ...

INTRODUCTION Circulating lipoprotein (a) (Lp(a)) is a recognized risk factor for cardiovascular disease (CVD). Tibolone, a synthetic steroid, may lower Lp(a) levels; however, evidence of the effects of tibolone on Lp(a) still remain to be defined. Therefore, we investigated the effects of tibolone treatment on circulating Lp(a) levels in postmenopausal women. METHODS The search included PUBME...

OBJECTIVE To compare the effects of tibolone, estriol and conventional hormone replacement therapy (HRT) on mammographic parenchymal density in postmenopausal women. DESIGN AND SETTING This was a non-randomised, prospective, longitudinal, comparative study conducted at two specialist outpatient clinics in Chile. PATIENTS AND PARTICIPANTS 210 non-obese, postmenopausal women aged <65 years wi...

OBJECTIVE To compare the effects of tibolone and continuous combined hormone therapy on circulating sex steroids and their binding proteins and their relationship to mammographic density. STUDY DESIGN A prospective, double-blind placebo-controlled study. A total of 166 postmenopausal women were equally randomized to receive tibolone 2.5 mg, estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA)...

INTRODUCTION Many postmenopausal women who are on hormone replacement therapy discontinue medications due to vaginal bleeding. Tibolone, a synthetic steroid, has minimal stimulatory effect on the endometrium. The aim of this study was to assess the effects of continuous HRT regimen and tibolone on the onset of vaginal bleeding and vaginal maturation value. MATERIALS AND METHODS A total of 150...

OBJECTIVE A prospective randomized controlled trial was conducted to evaluate the effect of low dose of tibolone on the histology, expression of estrogen (ER) and progesterone receptors (PR) and Bcl-2 protein, in endometrium of postmenopausal women. METHOD Forty postmenopausal women consented to treatment and were allocated into two groups of 20 women: Group 1 (Control) without hormone replac...

Experimental osteopenia caused by ovariectomy in rats may reflect postmenopausal bone changes, which are the effect of osteogen deficiency. The aim of the present study was to investigate the effects of tibolone (0.25 mg/kg/day and 2.5 mg/kg po) administered for 4 weeks on the development of osteopenia caused by bilateral ovariectomy in 3-month-old female Wistar rats. The experiments were carri...

Central nervous system hormones have been linked to premenstrual syndrome (PMS) and beta-endorphin (beta-EP) is thought to be involved in the pathophysiology. We have tested the efficacy of the synthetic steroid Org OD 14 (tibolone) in the treatment of PMS. This prospective, randomized, placebo-controlled, double-blind cross-over study included 18 ovulatory women with PMS as ascertained by a vi...

INTRODUCTION Tibolone is a synthetic steroid, used with increasing frequency to treat symptoms of menopause, including patients with solid-organ transplants who are taking concurrent immune suppression. To the best of our knowledge, there are no reported drug interactions between tibolone and tacrolimus, one of the principal immune suppressants used in kidney transplantation. CASE PRESENTATIO...

introduction: many postmenopausal women who are on hormone replacement therapy discontinue medications due to vaginal bleeding. tibolone, a synthetic steroid, has minimal stimulatory effect on the endometrium. the aim of this study was to assess the effects of continuous hrt regimen and tibolone on the onset of vaginal bleeding and vaginal maturation value. materials and methods: a total of 150...