Circadian rhythms optimize physiology and health by temporally coordinating cellular function, tissue function, and behavior. These endogenous rhythms dampen with age and thus compromise temporal coordination. Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms. Erratic eating patterns can disrupt the temporal coordination of metabol...

Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Droso...

Time-restricted feeding (TRF) initiated early during the dark phase prevents metabolic consequences of a high-fat diet in rodent models. However, delaying initiation TRF, akin to breakfast skipping humans, is unclear. We assigned 8-week-old male C57BL/6J mice ( n = 192) chow or ad libitum (AL) for 4 weeks, before randomization continue AL 10 h at lights off (TRFe) 4-h after (TRFd) further 8 wee...