The therapy of T. vaginalis infections was revolutionized by the discovery of metronidazole (Cosar, Julou, and Benazet, 1959). The course recommended as standard treatment has been 200 mg. orally three times daily for 7 days (Rodin, King, Nicol, and Barrow, 1960). In a trial by Csonka (1971), it was shown that, after a single oral dose of 2 g. metronidazole (Flagyl ), an 82 per cent. cure rate ...

Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients...

Both study designs were randomized, double-blind, placebo-controlled trials qualifying as a level of evidence Ia. In the study by Martinez, Franceschini, Patta, Quintana, Gomes, et al. (2009), half of the women received a single dose of tinidazole (2g) in addition to 2 placebo capsules while half received tinidazole (2g) supplemented with 2 capsules containing L. rhamnosus GR-1 and L. reuteri R...

Background: Periodontitis is a chronic bacterial infection destroying tooth-supporting tissues. Like metronidazole, tinidazole (TNZ) also effective in treating periodontitis. The preparation of polymeric nanoparticles containing TNZ helps to improve the solubility and increase bioavailability drug. Objectives: This study aimed formulate optimize evaluate their physicochemical properties. Materi...

Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a long...