Introduction Due to complications of currently available therapies, the clinical impetus to engineer adipose tissue for the correction of soft tissue defects is high. Unfortunately, poor survival of in vitro-engineered adipose tissue after transplantation is still a major hurdle for clinical use. The main reason for this poor survival is postulated to be insufficient vascularization. In this st...

There is a critical need for tissue engineered replacements for diseased and degenerated intervertebral discs in order to assuage low back pain while restoring function to the spine. Despite progress by many research groups, it remains a challenge to engineer a replacement tissue that can withstand the complex, demanding loading environment of the spine. Due to the hierarchical organization of ...

Arthroplasty is currently the only surgical procedure available to restore joint function following articular cartilage and bone degeneration associated with diseases such as osteoarthritis (OA). A potential alternative to this procedure would be to tissue-engineer a biological implant and use it to replace the entire diseased joint. The objective of this study was therefore to tissue-engineer ...

The design and application of hyaluronic acid (HA)-based scaffolds to control cell response and construct ideal tissue engineering products have been of great interest in the past few decades. This review provides an overview of the biological properties of HA to better understand how to engineer a cell-scaffold composite that is qualified in tissue engineering; important tissue engineering app...

The creation of new technologies that serve humanity holds the potential to help end global poverty. Unfortunately, relatively little is done in engineering education to support engineers' humanitarian efforts. Here, various strategies are introduced to augment the teaching of engineering ethics with the goal of encouraging engineers to serve as effective volunteers for community service. First...

Attached to this letter, please find an insolation sensitivity study of the HI-STORM EHT thermal model for PFS. We trust that the above information fulfills the verbal commitment made by us in an earlier telecon.