INTRODUCTION The mechanical characterization of soft biological tissues is essential to a number of medical applications, such as surgery planning, surgical training deploying virtual reality based simulators, or diagnosis. Quantitative data sets are available on the in-vivo mechanical properties of soft tissues in animal organs, but very limited data are available on the behavior of soft tissu...

Closed-form constitutive models are currently the standard approach for describing soft tissues’ mechanical behavior. However, there inherent pitfalls to this approach. For example, explicit functional forms can lead poor fits, non-uniqueness of those and exaggerated sensitivity parameters. Here we overcome some these problems by designing deep neural networks (DNN) replace such expert models. ...

Tissue Sealants In article number 2100803 by Boaz Mizrahi and co-workers, an elastic biodegradable sealant is designed mixing two complementary neat (solvent-free) star shape prepolymers. This mixture, which hardens in several seconds, offers advantages over existing tissue sealants, including excellent mechanical properties degradation behavior, minimal cytotoxicity vitro biocompatibility vivo.

To optimize the mechanical properties and integrity of tissue-engineered aortic heart valves, it is necessary to gain insight into the effects of mechanical stimuli on the mechanical behavior of the tissue using mathematical models. In this study, a finite-element (FE) model is presented to relate changes in collagen fiber content and orientation to the mechanical loading condition within the e...

BACKGROUND AND OBJECTIVES Few quantitative studies have investigated the temperature dependent viscoelastic properties of cartilage tissue. Cartilage softens and can be reshaped when heated using laser, RF, or contact heating sources. The objectives of this study were to: (1) measure temperature dependent flexural storage moduli and mechanical relaxation in cartilage, (2) determine the impact o...

Performance of various functions of the tissue structure depends on porous scaffold microstructures with specific porosity characteristics that influence the behavior of the incorporated or ingrown cells. Understanding the mechanical properties of porous tissue scaffold is important for its biological and biomechanical tissue engineering application. This paper presents a computer aided charact...

Musculoskeletal tissues respond to optimal mechanical signals (e.g., strains) through anabolic adaptations, while mechanical signals above and below optimal levels cause tissue catabolism. If an individual's physical behavior could be altered to generate optimal mechanical signaling to musculoskeletal tissues, then targeted strengthening and/or repair would be possible. We propose new bioinspir...

Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velo...

All the human blood vessels are surrounded by adipose tissue. Therefore in biomechanics of blood vessels, it is important to deal not only with the constitutive modelling of blood vessels as such but also with the mechanical properties of surrounding tissue. In this study, mechanical response of human perivascular adipose tissue that surrounds the abdominal aorta is concerned. From the performe...

Injectable hydrogels as an important class of biomaterials have gained much attention in tissue engineering. However, their crosslinking degree is difficult to be controlled after being injected into body. As we all know, the strongly influences physicochemical properties hydrogels. Therefore, developing injectable hydrogel with tunable vivo for Herein, present a dual strategy prepare step-by-s...