The biological activities of tocotrienols are receiving increasing attention. Herein, we report the efficacy of a mixed-tocotrienol diet against prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) mouse model. Male TRAMP mice, 8 wk old, were fed 0.1%, 0.3%, or 1% mixed tocotrienols in AIN-76A diet up to 24 wk old. Likewise, a positive control group consisting of male ...

There is growing evidence showing that prostate cancer cells have perturbed cholesterol homoeostasis, accumulating cholesterol to promote cell growth. Consequently, cholesterol-lowering drugs such as statins are being evaluated in prostate cancer treatment. Furthermore, natural products such as betulin (from birch tree bark) and tocotrienol (a minor form of vitamin E) have been shown to lower c...

Background: Studies on the cholesterol lowering activity of tocotrienols have yielded mixed results, with some showing cholesterol lowering effect while some showing no activity. Aim: A randomized, doubleblind, parallel group study was conducted to investigate the cholesterol lowering activity of tocotrienols. Methods: Thirtytwo hypercholesterolemic subjects were randomly assigned to orally r...

The effects of tocotrienols on murine liver cell viability and their apoptotic events were studied over a dose range of 0-32 microg mL(-1). Normal murine liver cells (BNL CL.2) and murine liver cancer cells (BNL 1ME A.7R.1) were treated with tocotrienols (T(3)), alpha tocopherol (alpha-T) and the chemo drug, Doxorubicin (Doxo, as a positive control). Cell viability assay showed that T(3) signif...

The antioxidant activities of natural d-alpha-tocopherol, mixed tocopherols and tocotrienols, and formulations comprising all forms of vitamin E, providing 400 IU, were determined employing an improved oxygen radical absorbance capacity (ORAC) assay using fluorescein (FL) as the fluorescent probe, randomly methylated beta-cyclodextrin (RMCD), 2,2'-azobis(2-amidino-propane)dihydrochloride (AAPH)...

Inflammation is an organism's response to environmental assaults. It can be classified as acute inflammation that leads to therapeutic recovery or chronic inflammation, which may lead to the development of cancer and other ailments. Genetic changes that occur within cancer cells themselves are responsible for many aspects of cancer development but are dependent on ancillary processes for tumor ...

The utilization of palm oil products in Indonesia is still limited to the production crude (CPO) and food products, while derivative such as red (RPO) have not been a concern. RPO consists palmitate, -tocopherol, oleic, -tocotrienols, linoleate, carotene, -tocotrienol, -tocotrienol compounds, these compounds act like vitamins antioxidants. aim this article examine potential for developing oil-b...

Inflammation is the cause and/or result of many diseases in peripheral tissues and central nervous system. Recent findings suggested that inflammation tissue induces an inflammatory response brain activates glial cells, which, turn, induce neuronal cell dysfunction. Therefore, anti-inflammatory compounds are important for suppression chronic prevention disease. The present study revealed microg...