Catechols are substances with a 1,2-dihydroxybenzene group from natural or synthetic origin. The aim of this study was to determine whether catechols (4-methylcatechol, 4-nitrocatechol, 2,3-dihydroxynaphthalene) and the antiparkinsonian drugs, entacapone and tolcapone, at doses 150 to 300 mg/kg/day, for 3 days, are able to enhance their own glucuronidation. The induction potency of catechols on...

Inhibitors of COMT are clinically used for the treatment Parkinson’s disease. Here, we report first natural pentacyclic triterpenoid-type inhibitors and their structure-activity relationships inhibition mechanism. The most potent compounds were found to be oleanic acid, betulinic acid celastrol with IC50 values 3.89–5.07 μM, that acted as mixed (uncompetitive plus non-competitive) COMT, represe...