the goal of this study was to evaluate the effects of quercetin and acth injection on prevention of development of morphine tolerance and dependence in mice. in this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10, 25 mg/kg, ip), acth (1, 2.5, 5 iu/mice, i.p.), or combination of quercetin (5 mg/kg) and acth (1 iu/mice) once a day for four days. tolerance ...

Introduction: Different mechanisms are involved in stress induced analgesia (SIA) and hyperalgesia (SIH). Repeated stress induces development of tolerance to SIA. The role of HPA axis and Gs signaling pathway in these effects are investigated in the current study. Methods: Forced swim stress (5 min/day) in water (20±1 ºC) was employed to adult male Wistar rats (200-250 g). The nociceptive t...

development of a green belt with suitable plant species around the source of emission can mitigate the atmospheric contamination. selection of such plant species are required to combat air pollution based on their tolerance level. present study was undertaken to evaluate the tolerance level of higher plants in east of esfahan city, iran, during 2011 in terms of assessing air pollution tolerance...

introduction: different mechanisms are involved in stress induced analgesia (sia) and hyperalgesia (sih). repeated stress induces development of tolerance to sia. the role of hpa axis and gs signaling pathway in these effects are investigated in the current study. methods: forced swim stress (5 min/day) in water (20±1 ºc) was employed to adult male wistar rats (200-250 g). the nociceptive thres...

Introduction: Topiramate is an anti-convulsant drug, which produces its effects via glutamate metabotropic receptors inhibition and/or GABA receptor excitation. In the present study, attempts were made to investigate the effects of topiramate on the tolerance to morphine-induced analgesia activity in male NMRI mice (20-30 g). Methods: Hot plate method was chosen for the study. First of all t...

Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance and sensitization to the rewarding effects of morphine.  Methods: The rewarding effects of morphine and isoniazid were assessed using a Condi...

Repeated administration of the relatively low-efficacy micro-opioid receptor agonist morphine induces tolerance to its antinociceptive effects. High-efficacy agonists such as D-Ala2NMePhe4,Gly-ol5 (DAMGO) have been shown to be less effective at producing tolerance, suggesting that different neural mechanisms underlie tolerance to these agonists. However, the correlation between agonist efficacy...

long-term exposure to opiates induces physical dependence and tolerance. the main goal of this study was to evaluate the effects of dextromethorphan and midazolam and their combination on morphine tolerance and dependence in mice. different groups of mice were rendered randomly and received morphine (50 mg/kg, sc), morphine (50 mg/kg, sc) + dextromethorphan (25,50 or 75 mg/kg, ip), morphine (50...

In software development process we come across various modules. Which raise the idea of priority of the different modules of a software so that important modules are tested on preference. This approach is desirable because it is not possible to test each module regressively due to time and cost constraints. This paper discusses on some parameters, required to prioritize several modules of a sof...