We investigated the susceptibility of 4-nitroquinoline 1-oxide (4-NQO)-induced tongue carcinogenesis in male CB6F1-Tg-rasH2 @Jcl mice (Tg mice). The Tg mice were administered 4-NQO (20 p.p.m. in drinking water) for 2, 4, 6 or 8 weeks, and thereafter they were untreated up to week 24. At week 24, a higher incidence (80%) of tongue neoplasm with dysplasia was noted in the mice that received 4-NQO...

  Background and Objectives: Squamous cell carcinoma of the tongue (SCCOT) is the most common malignant neoplasm in oral cavity. At the time of the diagnosis of SCCOT regional metastases with a high mortality rate are common, which is due to the extensive lymphatic system drainage of the tongue. Although the level of healthcare has significantly improved, the survival rate is still low with an...

BACKGROUND Brachytherapy for patients with early tongue cancer is an accepted method of treatment. PATIENTS AND METHODS The records of 409 patients with T1/2N0M0 tongue cancer treated with brachytherapy between 1978 and 2004 were reviewed. RESULTS The overall and disease-free 5-year survival rates were 82.3% and 64.6% for patients with T1 disease, and 72.2% and 56.0% for patients with T2 di...

Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old (1 to 6%). This report describes a case of squamous cell carcinoma, staged T2N1M0 (stage III), involving the lateral border and dorsal surface of the tongue of a 25-yearold white female patient, with no ...

Sir, Multiple myeloma is a monoclonal B-cell neoplasm, which is characterized by autonomous proliferation of immunoglobulin-secreting plasma cells, capable of synthesizing amyloidogenic light chains (AL). AL amyloidosis is characterized by extracellular deposition of eosinophilic, homogeneous, amorphous material composed of fibrillary protein, containing light chain fragments (1). The oral clin...

A variety of Tand B-cell neoplasm can involve the skin and the term “primary cutaneous lymphoma” refers to the disorder that present in the skin with no evidence of extracutaneous disease at the time of diagnosis [1,2]. Among them, primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) is characterized with skin lesions on one or both legs. In patients presenting with a single ...

A compromised immune system places individuals at a significantly higher risk for many infectious processes. Immunosuppression also increases the risk of malignancy due to the body's decreased ability to perform its normal immunosurveilance and response. It is therefore imperative to have regular thorough evaluations of these patients, as slight abnormalities may be the early signs of infection...

Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate. We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck. The tumor was resected through the oral cavity with wide margins and dissection. The neck metastasis was trea...

Adenoid cystic carcinoma is a common malignant neoplasm originated from salivary glands. The clinical and pathological findings typical of this tumor include slow growth, perineural invasion, and potential local recurrence. It accounts for nearly 2% to 4% of head and neck area tumors. In minor salivary glands it usually affects the palate. We described herein the case of a patient who presented...

Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the most commonly affected region in pediatric patients with the tongue and orbit affected most commonly. Herein we pres...