BACKGROUND Oligodontia is a severe form of tooth agenesis characterized by the absence of six or more permanent teeth. Oligodontia has complex etiology and variations in numerous genes have been suggested as causal for the condition. METHODS We applied whole-exome sequencing (WES) to identify the cause of oligodontia in a 9-year-old girl missing 11 permanent teeth. Protein modeling and functi...

Many authors such as Morgenstern, ROse, Ahrens and N or b e r g have reported about the origin of the permanent tooth germs but the later development of this dentition has not been well illustrated. And there are few, if any, detailed studies concerning the position changes during development of permanent tooth germs. The present author previously (1957) postulated that deciduous tooth germs or...

Teeth develop from epithelium and neural crest-derived mesenchyme via a series of reciprocal epithelial-mesenchymal interactions. The majority of the dental papilla of the tooth has been demonstrated to be of neural crest origin. However, non-neural crest cells have also been observed in this region from the bud stage of tooth development onwards. The number of these non-neural crest-derived ce...

Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of se...

Tooth loss or damage, such as that caused by dental caries and periodontal disease, can cause fundamental problems with oral functions. The development of regenerative therapy for tooth tissue repair and whole-tooth replacement is currently considered a novel treatment with the potential to fully recover tooth function. Several mesenchymal stem cell-like cell types have been identified in oral ...

Members of the transforming growth factor-beta family (e.g. TGF-beta, BMP and activin) are critical regulators of tooth morphogenesis. The basic TGF-beta signaling engine consists of a receptor complex that activates Smads and a Smad-containing complex that controls transcription of the downstream target genes. Little is known about the expression of endogenous Smads during tooth morphogenesis....

The mammalian tooth forms by a series of reciprocal epithelial-mesenchymal interactions. Although several signaling pathways and transcription factors have been implicated in regulating molar crown development, relatively little is known about the regulation of root development. Four genes encoding nuclear factor I (NFI) transcription-replication proteins are present in the mouse genome: Nfia, ...

odontogenic tumors contain a heterogeneous collection of lesions that are categorized from hamartomas to benign and malignant neoplasms of inconstant aggressiveness. odontogenic tumors are usually extraordinary with assessed frequency of short of 0.5 cases/100,000 population for every year. the lesions such as odontogenic tumors are inferred from the components of the tooth-structuring contrapt...

This clinical report describes the delayed development of a maxillary second premolar. The premolar developed when the patient was between the ages of 12 and 16 years. The development of the tooth was discovered from a panoramic radiograph taken when the patient was 17 years, 1 month of age. Previous to this discovery, the tooth had been diagnosed as congenitally missing. The transition from th...