نتایج جستجو برای: topical immunotherapy
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Non-keratinocyte cutaneous malignancies including breast cancer metastasis and melanoma in situ are often poor surgical candidates due to their anatomical location, size the morbidities associated with surgery. Imiquimod, a toll-like receptor 7 agonist, is used for treatment of these malignancies, which activates innate immunity skin. However, imiquimod’s modest effect on activation adaptive li...
One hundred thirteen tumors in 5 dinitrochlorobenzene (DNCB)-sensitized patients with multiple basal cell carcinomas were treated with topical DNCB. Thirty-six of the 113, or 32%, showed complete clinical regression, for periods of 5 to 18 months. An additional 29% (33 or 113) showed partial regression. DNCB induced only 15 to 25% complete regression in 4 of the 5 patients, whereas 21 of 30, or...
The syngeneic orthotopic murine bladder cancer model MB49 is hampered by unreliable tumor implantation. We optimized this model by a simple modification of the standard implantation technique in three groups of mice. Fifty thousand (group I), 20,000 (group II), or 10,000 (group III) tumor cells were implanted into cauterized bladders by transurethral instillation, and dwell time was prolonged t...
The current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caus...
BACKGROUND Cryotherapy has been accepted as the mainstay in treating periunugal and palmoplantar warts. The major drawback of cryotherapy is the requirement of several unbearably painful treatment sessions. OBJECTIVE This study aims to assess the efficacy of immunotherapy in viral wart treatment, as an adjunctive method to cryotherapy. METHODS Retrospective chart review was performed on 124...
The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation. The consensus process consisted of a nominal group process and a DELPHI procedure. Management of AE must consider the individual symptomatic variability of the disease. Basic therapy is focused on hydrating topical treatment, and ...
The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation. The consensus process consisted of a nominal group process and a DELPHI procedure. Management of AE must consider the individual symptomatic variability of the disease. Basic therapy is focused on hydrating topical treatment, and ...
Sir, Recalcitrant warts remains a major therapeutic challenge for patients as well as for dermatologists, and an effective, painless, atraumatic treatment modality is needed world-wide. Topical immunotherapy has for years been used with some success in the treatment of resistant warts (1). Dinitrochlorobenzene (DNCB) was the ®rst contact sensitizer to be used but diphenylcyclopropenone (DCP) is...
The topical immunotherapy is used to treat alopecia areata and recalcitrant warts since the 1970s. Diphencyprone is a contact sensitizer used to treat dermatological conditions resulting from as altered immunological state, such as extensive alopecia areata, being partially effective and safe. Side effects include local eczema with blistering, regional lymphadenopathy and contact urticaria. Rar...
Observational Study of Topical Imiquimod Immunotherapy in the Treatment of Difficult Lentigo Maligna
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