BACKGROUND Methanol toxicity poses a significant public health problem in developing countries, and in Southeast Asia, where the most common source of poisoning is via adulterated liquor in local drinks. Methanol toxicity can have devastating visual consequences and retinal specialists should be aware of the features of this toxic optic neuropathy. The authors report a case of severe systemic m...

Non-Hodgkin's lymphoma may have ocular involvement but optic nerve and chiasmal disease is unusual. Determining the cause of the neuropathy in this group of patients presents major difficulties despite modern neuroimaging and immunocytochemistry. Two patients with NHL are presented; one had an anterior chiasmal syndrome and the other bilateral optic nerve involvement. The first patient was thou...

As is common knowledge, there is an argument as to whether or not the toxic radical cyanide is an important aetiological agent responsible for the development of some of the conditions grouped under the term toxic amblyopia. There are arguments and counterarguments, and it would appear useful at this stage to state the evidence for and against cyanide as a cause of these conditions. The argumen...

Three cases of bilateral optic neuropathy were reported recently to the Netherlands Pharmacovigilance Centre Lareb. Patient 1, a 54 year old man, had blurred vision 34 days after he was given a third dose of infliximab for rheumatoid arthritis. He was also taking leflunomide, prednisone, naproxen, diazepam, fluoxetine, famotidine, and metoprolol, and acetaminophen or codeine. He had 20/30 visio...

Ethambutol and isoniazid are antimicrobial agents used to treat multi-drug-resistant tuberculosis. The most commonly recognized toxic effect of these drugs is optic neuropathy, usually manifesting as a decrease in visual acuity, deficits in color vision and ceco central scotomas. Total visual loss is a rare complication that can be related to ethambutol and isoniazid toxicity. As precipitating ...

Dear Editor: We read with great interest, the case report on ischemic optic neuropathy (1). We would like to add a few points concerning the blood supply of the optic nerve and the correlation with the development of post-operative ischemic neuropathy. Actually, the perioperative or post-operative vision loss (postoperative ischemic neuropathy) is most likely due to ischemic optic neuropathy. I...

treated with corticosteroids was found to have a statistically significant higher mortality rate compared to the placebo group [4]. This means that not only is the treatment with high dose corticosteroids not beneficial in cases of TON, it may in fact be harmful when given to patients with severe head trauma and brain injury. We present the case of a patient with bilateral TON. Bilateral TON is...

ABSTRACT Methanol poisoning is a serious problem due to its high mortality and revalence of health sequelae among survivors. Death from methanol has been reported in 8-36% permanent vision loss observed 20- 0% acute trauma Formic acid that builds up the optic nerve can disrupt visual system cause neuropathy. Vision painless usually occurs both eyes within one three days. This Systematic Review ...