Abstract Background Tricuspid regurgitation (TR) is frequent among patients with severe left-sided valvular heart disease (LS-VHD). Objectives This study sought to assess TR frequency, management and outcome in this population. Methods Among 6883 LS-VHD or previous intervention the EURObservational Research Programme prospective VHD II survey, we analyzed frequency grade of according LS-VHD, 6-...

PURPOSE To evaluate the plasma level of different forms of soluble urokinase plasminogen activator receptor (suPAR) as discriminators between malignant, borderline, and benign ovarian tumors and as prognostic markers in patients with ovarian cancer. EXPERIMENTAL DESIGN The different suPAR forms were measured in preoperative plasma samples obtained from 335 patients with adnexal lesions using ...

objective: the present study aimed to compare the effectiveness of metacognitive therapy (mct) and cognitive-behavior therapy (cbt) in treating iranian patients with major depressive disorder (mdd). methods: thirty three outpatients meeting dsm-iv-tr criteria for mdd without any other axis i and ii disorders were randomly assigned to one of three treatment conditions, i.e. mct, cbt and pharmaco...

Naturally arising CD25+ CD4+ regulatory T cells (TR) play an important role in the prevention of autoimmunity. TCR specificity is thought to play a critical role in TR development and function, but the repertoire and specificity of TR TCRs remain largely unknown. We find by sequencing of TRAV14 (Valpha2) TCRalpha chains associated with a transgenic TCRbeta chain that the TRand CD25- CD4+ TCR re...

OBJECTIVE Our objective was to evaluate the effectof two different hemostatic devices on radial artery outcomes after transradial catheterization. BACKGROUND Radial artery occlusion is an infrequent but discouraging complication of transradial access. It is related to factors such as sheath-to-artery ratio and its incidence is decreased by the administration of heparin. It usually does not le...

Tumor antigen-specific CD4(+) T cells generally orchestrate and regulate immune cells to provide immune surveillance against malignancy. However, activation of antigen-specific CD4(+) T cells is restricted at local tumor sites where antigen-presenting cells (APCs) are frequently dysfunctional, which can cause rapid exhaustion of anti-tumor immune responses. Herein, we characterize anti-tumor ef...

BACKGROUND Tricuspid regurgitation (TR) and right ventricular (RV) dysfunction adversely affect outcomes in patients with heart failure or mitral valve disease, but their impact on outcomes in patients with aortic stenosis treated with transcatheter aortic valve replacement has not been well characterized. METHODS AND RESULTS Among 542 patients with symptomatic aortic stenosis treated in the ...

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Treatment-resistant major depressive disorder (TR-MDD) is a complex condition, with very low remission rates. In recent years some studies have been conducted on the implementation of cognitive behavioral therapy and psychodynamic psychotherapy interventions via the Internet to MDD patients, and results have been promising. However, there have been no studies in patients with TR-MDD nor with th...

BACKGROUND Traditional vital signs such as heart rate, blood pressure, and oxygen saturation are not ideal for timely and accurate assessment of physiologic status after trauma (TR) and hemorrhagic shock (HS). Analysis of the complex beat-to-beat variability present in the heart-rate time series has been proposed as a "new vital sign" in this setting. We determined the effect of chest TR and HS...