The purpose of this study was to determine the pharmacokinetics of tramadol and its metabolite M1 after intravenous and intramuscular administration to llamas. Tramadol, a centrally acting analgesic whose efficacy is a result of complex interactions between opiate, adrenergic and serotonin receptor systems, has been used clinically to treat moderate to severe pain in humans. The pharmacokinetic...

We have compared codeine and tramadol in a prospective, double-blind study of postoperative analgesia in 75 patients after elective intracranial surgery. Twenty-five patients received codeine 60 mg, tramadol 50 mg or tramadol 75 mg i.m. Patients receiving codeine had significantly lower pain scores over the first 48 h after operation (P < 0.0001). Although there was no difference in visual anal...

We report an unusual case of respiratory depression and prolonged apnea after a single, 50-mg intravenous dose of tramadol. Shortly after an uneventful surgery and anesthesia, the patient was administered intravenous tramadol. Soon after the tramadol injection, the patient became apneic, did not respond to verbal command, and started exhibiting oxygen desaturation. He was quickly administered 1...

OBJECTIVE This study was designed to compare the effects of dexketoprofen, lornoxicam, and diclophenac sodium on postoperative analgesia and tramadol consumption in patients receiving postoperative patient-controlled tramadol after a major abdominal surgery. METHODS Eighty patients were randomized to receive one of the four study drugs. Patients in group dexketoprofen (DT) received IV 50 mg d...

Electrochemical oxidation of tramadol at pencil graphite electrode has been investigated using cyclic, differential pulse and square wave voltammetric techniques. In pH 9.2 phosphate buffer, tramadol showed an irreversible oxidation peak at 0.77 V. The dependence of the current on pH, concentration and scan rate was investigated to optimize the experimental conditions for the determination of t...

abstract introduction: frequency of tramadol intoxication is increasing as a result of its use as a drug for suppression of withdrawal symptoms by opioids abusers and its wide accessibility of this drug. tramadol intoxication can lead to death and, therefore, early identification of its clinical manifestations is crucial since early detection of the intoxication and its treatment could improve ...

tramadol is a synthetic analgesic of opioids which has more flexible mechanisms of action than typical opioids. since it has been reported in previous study that typical opioids like morphine can affect the bone homeostasis, it is worthwhile to examine the effects of tramadol on tooth movement. in this study we investigated effects of tramadol on orthodontic tooth movement in rats.30 male wista...

Tramadol is a novel centrally acting opioid analgesic used for the treatment of mild to severe pain. This drug is the most prescribed opioid worldwide. It has been approved as an analgesic in Iran since 2002. Unfortunately Tramadol dependency has become very common in Iran in various age groups and genders but in particular is abused among the young generation. Overdose of Tramadol is a well-kn...

BACKGROUND Tramadol hydrochloride (tramadol) is a synthetic opioid analgesic with a relatively weak affinity at opioid receptors. At analgesic doses, tramadol seems to cause little or no respiratory depression in humans, although there are some conflicting data. The aim of this study was to examine whether tramadol causes dose-dependent inhibitory effects on the ventilatory carbon dioxide respo...

Tramadol is a centrally acting analgesic selective for the μ-opioid receptor with antidepressant and dopamine releasing actions. In Egypt, dependence on and abuse of tramadol presents a challenging health problem and the drug is included in the narcotic analgesic schedule III. In this study, a sample of commercially available honey was brought to the laboratory of narcotics and poisons on the s...