BACKGROUND In vitiligo, melanocytes are gradually lost in depigmented macules of the skin. The disappearance of melanocytes has, however, not been clearly observed and consequently the aetiology of the disease (autoimmune, neural, cytotoxic) is still elusive. The starting point of vitiligo macules is frequently determined by local conditions such as wounds and excoriations, but may also follow ...

A 10-year-old Japanese girl presented with a rhomboid-shaped brown macule, 4x3 mm in size, on the sole of the right foot. Dermoscopic examination revealed a number of black dots and globules on the ridges of the skin, marking an area of symmetrical brown pigmentation. On the periphery, a streak-like arrangement of black dots/globules on the brown pigmentation was observed along the ridges, simu...

Acquired perforating dermatosis (APD) is a disorder of transepidermal elimination keratin, collagen or elastic fibers. APD mainly associated with diabetes mellitus and chronic kidney disease. We present the case 66-year-old male, poorly controlled diabetic peripheral arterial disease, obesity, hypertension, Cushing's syndrome disease requiring hemodialysis who develops an acquired dermatosis. D...

Elastosis Perforans Serpiginosa (EPS) is a rare skin disease characterised by hyperkeratotic papules, transepidermal elimination of abnormal elastic fibres, and focal dermal elastosis. The aetiology is unknown, but an association with underlying systemic disorders, including Down syndrome has been described. Treatment is often difficult. A 45-year old man with Down syndrome presented with symme...

Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-p...

The effectiveness of using semipermeable membrane in preterm infants to reduce transepidermal losses Gurgel EPP, Caetano JÁ, Lopes MVO, Rolim KMC, Almeida PC, Magalhães FJ, Barreto JO Rev Esc Enferm USP 2011; 45(4):817-23 www.ee.usp.br/reeusp/ The effectiveness of using semipermeable membrane in preterm infants to reduce transepidermal losses* O r ig in a l a r t ic l e EFICÁCIA DO USO DE MEMBR...

The purpose of this study was to evaluate transepidermal water loss, skin hydration and skin pH in normal polish ponies. Twelve ponies of both sexes were examined in the study. Measurements were taken from seven different sites: the neck region, the shoulder, thorax, lumbar, inguinal, lip region and the pinna. In each of the regions transepidermal water loss (TEWL), skin hydration and skin pH w...