Methionine sulfoxide reductases (MSRs) catalyse the reduction of oxidized methionine residues, thereby protecting proteins against oxidative stress. Accordingly, MSRs have been associated with stress responses, disease, and senescence in a taxonomically diverse array of organisms. However, the cytosolic substrates of MSRs in plants remain largely unknown. Here, we used a proteomic analysis stra...

Glutathione transferases (GSTs) form a superfamily of multifunctional proteins with essential roles in cellular detoxification processes and endogenous metabolism. The distribution of fungal-specific class A GSTs was investigated in saprotrophic fungi revealing a recent diversification within this class. Biochemical characterization of eight GSTFuA isoforms from Phanerochaete chrysosporium and ...

Glutathione transferases (GSTs) represent a widespread multigenic enzyme family able to modify a broad range of molecules. These notably include secondary metabolites and exogenous substrates often referred to as xenobiotics, usually for their detoxification, subsequent transport or export. To achieve this, these enzymes can bind non-substrate ligands (ligandin function) and/or catalyze the con...

The input into the QIVIVE and Physiologically-Based kinetic dynamic models of drug metabolising enzymes performance their inter-individual differences significantly improve modelling performance, supporting development integration alternative approaches to animal testing. Bayesian meta-analyses allow generating integrating statistical distributions with human in vitro metabolism data for quanti...

Aphids heavily rely on their olfactory system for foraging behavior. Odorant-degrading enzymes (ODEs) are essential in preserving the acuity of aphids by removing redundant odorants antennae. Certain within this group stand out as being enriched and/or biased expressed antennae, such carboxylesterases (CXEs), cytochrome P450 (CYPs), glutathione S-transferases (GSTs), and UDP-glycosyltransferase...

The biotransformation of foreign substances (xenobiotic) including drugs in the body is divided into phase I, II and III. But phase II enzymes are playing a key role in the biotransformation of endogenous compounds and xenobiotics to easily excretable forms and also the metabolic inactivation of pharmacologically active substances. The phase II enzymes can perform biotransformation through conj...

background: glutathione s-transferases ( gsts ) have been investigated as potential carcinoma susceptible genes. however, the relationship between gsts ( gstm1 , gstt1 ) variants and gastric carcinoma (gc) risk has been controversial in chinese population. methods: a comprehensive literature search strategy (pubmed, chinese biomedical database, chinese national knowledge infrastructure, wan fan...

Introdução : A Diabetes tipo 2 (DM2) é uma desordem metabólica ocasionada pela disfunção das células beta pancreáticas que interferem na produção de insulina e/ou resistência dos órgãos alvos a esse hormônio. Níveis elevados radicais livres em conjunto com declínio defesas antioxidantes, presente DM2, podem ocasionar danos organelas celulares promovendo complicações da doença. As glutationas S-...

Paracetamol (acetaminophen, PCM) is a widely used over-the-counter analgesic and antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis. Oxidative stress is mediated by oxidative capacities of the PCM metabolite (N-acetyl-para-benzo quinoneimine, NAPQI), which covalently binds to proteins and other macromolecules to cause cellular damage. At low doses, NAPQI is ...

Two cDNA species, aggst1-5 and aggst1-6, comprising the entire coding region of two distinct glutathione S-transferases (GSTs) have been isolated from a 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) resistant strain (ZANDS) of Anopheles gambiae. The nucleotide sequences of these cDNA species share 80.2% identity and their derived amino acid sequences are 82.3% similar. They have been cla...