BACKGROUND: Airway remodeling in children with bronchial asthma is due to the effect of inflammatory mediators and growth factors on epithelium. Vitamin D (VitD) has immunomodulatory many diseases as asthma. The ant-inflammatory anti-fibrotic role VitD could prevent or improve air way asthmatic patients. AIM: study investigated supplementation expression transforming factor-beta (TGF-β), tumor ...

By definition, growth factors are polypeptides that modulate the proliferation of mammalian cells by acting on their receptors at low concentration. Based on similarities in their sequences and their receptors, growth factors can be divided into several superfamilies including platelet-derived growth factors, epidermal growth factors, insulin-like growth factors, the transforming growth factor-...

Abbreviations: 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyl ethyl ammonium bromide, (DMRIE); activation protein-1, (AP-1); Basement membranes, (BM); colony stimulating factor (CSF), dioleoylphosphatidyl ethanolamine, (DOPE); fibroblast growth factor, (FGF); growth hormone, (GH); Hepatocyte growth factor, (HGF); insulin-like growth factor-I, (IGF-I); interleukin-1, (IL-1); interleukin-6, (IL-6); ...

Abstract Background To compare the urinary biomarkers—beta 2-microglobulin (β2M), monocyte chemotactic peptide-1 (MCP-1), and transforming growth factor-beta (TGF-β1)—in outcome assessment of children with pelviureteric junction obstruction (PUJO) undergoing pyeloplasty. Methods A prospective study was conducted on PUJO who had pyeloplasty in a tertiary care center from July 2016 to March 2018....

This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β an...

Several mental conditions and depression, have been linked to immune response disorganization. However, it is unclear if particular mediators play a part in the etiopathogenesis of depression. Although there are no definite biomarkers diagnose current study sought logically evaluate possibility feasibility checking biomarker for depression be utilized hospitalized patients suspected In this nar...

Background: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. Objective: To evaluate the patterns of T-helper cytokines in patients suffering from chronic and acute brucellosis. Methods: In this cross-sectional study, 22 individuals w...

Background: Normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. Cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. The aim of t...

Background: Cytokines are glycoprotein compounds with an important role in inducing and regulating inflammation. Objectives: The present study aimed to measure the effect of Aloe vera alcoholic extracts on inflammatory cytokines rats fed a high-fat diet. Methods: Forty adult male Wistar were purchased randomly categorized into five groups, including two control groups (control diet (HFD) three ...