نتایج جستجو برای: transmission blocking vaccine
تعداد نتایج: 397418 فیلتر نتایج به سال:
Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates
Abstract Background Plasmodium vivax transmission-blocking vaccines (TBVs) are receiving increasing attention. Based on excellent activities of the PbPH (PBANKA_0417200) and PbSOP26 (PBANKA_1457700) antigens in berghei , their orthologs P. PVX_098655 (PvPH) PVX_101120 (PvSOP26), were selected for evaluation potential as TBVs. Methods Fragments PvPH (amino acids 22–304) PvSOP26 30–272) expressed...
Malaria is still one of the infectious diseases urgently requiring control and causes socioeconomic burdens on people residing in developing countries. Malaria vaccines are expected to control the disease. However, there is no effective vaccine available despite the intense efforts of malaria scientists. One strategy for a malaria vaccine is to prevent parasite spread by means of interfering wi...
Transmission of malaria parasites from humans to Anopheles mosquitoes can be inhibited by specific antibodies elicited during malaria infection, which target surface Plasmodium gametocyte/gamete proteins. Some of these proteins may have potential for vaccine development. Pvs48/45 is a P. vivax gametocyte surface antigen orthologous to Pfs48/45, which may play a role during parasite fertilizatio...
While attempting to clarify the confusion concerning the conceptualization of "blocking zeros" in state space in the recent literature, some new observations are made on the relationship between pole-zero cancellation and transmission blocking. An important distinction between uncontrollable and unobservable eigenvalue s is pointed out; and it is argued that the description of a Blocking Zero, ...
Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria elimination. High-titer functional antibodies are required against target antigens to achieve effective transmission-blocking activity. We have fused Pfs25, the leading malaria TBV candidate antigen to IMX313, a molecular adju...
The Lyme disease spirochete, Borrelia burgdorferi, inhabits the gut lumen of the tick vector. At this location the spirochete is exposed to host blood when a tick feeds. We report here on studies that were done with normal and complement-deficient (C3-knockout) mice to determine if the host complement system killed spirochetes within the vector. We found that spirochete numbers within feeding n...
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