The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...

objective: opioid consumption has been widely increasing across the globe; however, it can cause adverse effects on the body. morphine, an opioid, can reduce sex hormones and fertility. withania somnifera (ws) is a traditional herb used to improve sexual activities. this study strives to investigate the effect of ws on sex hormones and gonadotropins in addicted male rats. materials and methods:...

Background: Toxoplasma gondii is a zoonotic protozoan with worldwide distribution. Recent studies have shown that the transmission of T. facilitated by its ability to modify host’s behavior. Objectives: The present study aimed investigate effect infection on anxiety in an animal model and determine levels cortisol interleukin-17 (IL-17) rats. Methods: In this study, 40 rats were randomly alloca...

background: age-related differences in the ethoxyresorufin o-deethylase (erod) activity of cyp1a1 and its inducibility in rats may determine the toxic potential of acetaminophen.  this study was carried out to compare the effects of acetaminophen (apap) and β-naphthoflavone (βnf) on cyp1a1 activity in young and adult rats. methods: for this purpose, young and adult rats (n = four / group) were...

Objective: Foeniculum vulgare seed (F. vulgare) is a herbal plant which is used with phytoestrogene compounds for polycystic ovary syndrome (PCOS) treatment. In this research, renoprotective effect of the aqueous extract of Foeniculum vulgare (AEF) in experimental PCOS female rats is studied. Materials and Methods: Forty female rats were randomly divided into five groups. The first group served...

objective: methotrexate is an antimetabolite drug commonly prescribed for the various cancers and autoimmune diseases. despite its considerable therapeutic effects, nephrotoxicity is the most important side-effect of treatment with methotrexate. aquaporin1 is a water channel proteins which are present in mammalian kidney. raspberry fruit with antioxidant properties is able to protect biological...

Wound healing is a complex and dynamic process that includes multiple biological pathways has some successive periods. Most growth factor responsible for wound healing. Fibroblast positive effect on problems can be caused by diabetes. In the present study, we aimed to investigate exogenous bFGF supplementation serum TBARS, RSH NOx levels in hyperglysemic rats. Experiments were performed 30 male...

background and objective: diabetes mellitus is common endocrine disease cause learning and memory impairment. this study was done to evaluate the effect of quercetin on learning and memory in stz-induced diabetic rats was investigated. methods: in this experimental study, 40 male wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin -...

diabetes mellitus is a chronic disease which affects the healing ability of the pulp and periodontium. the aim of the present study was to assess the histopathologic response of dental pulp to pulp capping using mta or cem cement in diabetic rats. thirty two wistar male rats aged between 8 and 10 weeks (weight: 200-250g) were divided into two groups of diabetic (n=16) and healthy (n=16) animals...

background and objective: uterus of rat with polycystic ovary (pco) may show pathological features. we provided pathological evidence for the rat uterus with no-induced pco.    materials and methods: wistar rats (weighing 200-250 g) were kept diestrous to receive l-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. control group solely received saline (1 ml/kg, 9 days/once per ...