Murine peritoneal neutrophils (PMNs), elicited by i.p. injection of formalin-killed Corynebacteria parvum, spontaneously lyse teratocarcinoma targets through the secretion of reactive oxygen intermediates. Examination of effector-target interactions at the single cell level revealed that PMNs conjugated to tumor cells were 3-fold more frequently stained by nitroblue tetrazolium compared to nonc...

I n "Cultural Transmission, Disproportionate Prior Expos ure, and th e Evolu ti on of Cooperation," Mark (2002) claims to have "condueted a formal theoretical analysis that isolated the logic of cultural transmission (to] reveal an evolutionary force toward cooperation under conditions previously thought to make the evolution of cooperation impossible" (p. 324). The most striking aspect of Mark...

Congestion control plays an essential role in ATM networks to support di erent quality of service guarantees for a large variety of tra c types While for real time communications such as CBR and VBR services a preventive open loop congestion control mechanism is applied a reactive closed loop mechanism has been suggested for the ABR service class which was introduced aiming at data communicatio...

Resistance to the cytotoxic effects of many natural product drugs after exposure to a single agent is a common observation. The classes of drugs included in the "classic" multiple drug resistance phenotype are Vinca alkaloids, anthracyclines, epipodophyllotoxins, and antibiotics. We re port here the characterization of a human leukemic cell line (CEM/VM1) with "atypical" multiple drug resistanc...

National Cancer Institute, USPHS. Presented in part at the 62nd Annual Meeting of the American Association for Cancer Research, Inc., Chicago. 111..April 1971 (37). 2Career Development Awardee of the National Cancer Institute (IK4-CA-8245-05). 3The abbreviations used are: HMM, hexamethylmelamine [2,4,6tris(dimethylamino)-i-lriazine] (NSC-13875); TEM, triethylenemelamine [2,4,6-tris(l-aziridinyl...

IDIOPATHIC P ~ L M O N A R Y HEMosmERosls auto-antibody antigen reaction wi th t h e is now a well recognized clinical synlung as the "shock-organ." drome. It was first described by Virchow in ( 4 ) Soergel and Sommers (1962)"'sug1851. Ceelen' in 1931 reported the lint degested that the primary pathogenic mechtailed stud! of two c a m in children. anism is a congenital abnormality of alIt affec...

long-lasting Ser133 phosphorylation, suggesting the imSynapse-to-nucleus signaling leading to CREB-mediportance of the time integral of phospho-CREB. Possible ated transcription is important for neuronal plasticity. additional regulatory factors include the adaptors linking Nuclear CREB phosphorylation at Ser133 allows converCREB to the basal transcription complex, including the gence of multip...

Background Polyploid breeding is a powerful approach for Populus genetic improve-ment because polyploid trees have valuable characteristics, including better timber quality and a higher degree of stress resistance compared with their full-sib diploids. However, the genetic mech-anism underlying this phenomenon remains unknown. Objective To better understand the proteomic changes between Popul...

Kinetic data indicate that rabbit muscle glyceraldehyde d-phosphate dehydrogenase possesses two types of diphosphopyridine nucleotide-binding sites. The actual chemical reaction (oxidation-reduction) occurs at tight sites. Binding of DPN to loose sites activates the reaction at the tight sites. These results are consistent with the concept that the enzyme is “double headed,” with oxidation-redu...

The problem studied in this paper is as follows Consider a le stored in contiguous space on disk Given a list of pages to be retrieved from the le what is the fastest way of retrieving them It is assumed that adjacent pages on disk can be read with a single read request The straight forward solution is to read the desired pages one by one However if two or more pages are located close to each o...