We report herein the design, preparation and first applications of novel trityl tags with adjustable stability, efficient as protecting groups or MS analytes.

The synthesis, structure and reactivity of a new bipy thorium metallocene have been studied. The reduction of the thorium chloride metallocene [η(5)-1,3-(Me(3)C)(2)C(5)H(3)](2)ThCl(2) (1) with potassium graphite in the presence of 2,2'-bipyridine gives the purple bipy metallocene [η(5)-1,3-(Me(3)C)(2)C(5)H(3)](2)Th(bipy) (2) in good yield. Complex 2 has been fully characterized by various spect...

On the other hand, the less stabilized tris(4chlorophenyl)methyl cation (1 b) was reported to initiate the polymerization of isobutene3). In accordance, p-methoxy and p-methyl substituted tritylium ions do not initiate the polymerization of a-methylstyrene, in contrast to the less stable 1 a and 1 b4). Only for few reactive monomers, however, the initiation was proven to proceed via addition of...

Using carboranes as counterions, fluorinated benzyl-type carbocations such as (p-FC(6)H(4))(2)CF(+), (p-FC(6)H(4))(CH(3))CF(+) and fluorinated trityl ions are readily isolated for X-ray and IR structural characterization.

Understanding the interactions of trityl radicals with proteins is required to expand their biomedical applications. In this work, we demonstrate that the Finland trityl radical CT-03 binds to bovine serum albumin (BSA) in aqueous solution. Upon binding with BSA, CT-03 exhibits a much broader electron paramagnetic resonance (EPR) signal and this line broadening can be reversed by proteolysis of...

Human Eg5, a member of the kinesin superfamily, plays a key role in mitosis, as it is required for the formation of a bipolar spindle. We describe here the first in vitro microtubule-activated ATPase-based assay for the identification of small-molecule inhibitors of Eg5. We screened preselected libraries obtained from the National Cancer Institute and identified S-trityl-L-cysteine as the most ...