In this experiment, the effect o f betamethasone administered in the early postacute infection o f mice by Trypanosoma cruzi was studied. This drug was administered during 30 days after the 42nd day o f infection in a dose o f 0.15 mg/day. The betame­ thasone treatment did not cause fresh outbreaks o f parasitemia and the histopathological findings in the chronic phase were not different from t...

We have previously described alterations in the cytoskeletal organization of heart muscle cells (HMC) infected with Trypanosoma cruzi in vitro. Our aim was to investigate whether these changes also affect the regulation of the actin mRNAs during HMC differentiation. Northern blot analysis revealed that alpha-cardiac actin mRNA levels increased during cell differentiation while beta-actin mRNA l...

In order to identify Trypanosoma cruzi reservoirs in transmission areas, 60 mammals in Capital and San Luis del Palmar Departments, Corrientes, Argentina were studied. Primates, rodents, carnivores, marsupials and edentates were investigated, 40 of them living in captivity and 20 caught with traps in a rural area. The mammals were examined by xenodiagnosis and third or fourth instars nymphs of ...

ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, has often been linked to oral transmission through açai consumption. Molecular methods that allow fast and accurate identification of pathogen are important for detection presence parasite in this food. This study aimed optimize polymerase chain reaction (PCR)-based T. cruzi DNA pulp. Several dilutions DTU TcI trypomastigote fo...

Introduction: Trypanosoma cruzi is the agent of Chagas’ disease and affects approximately 6-8 million people worldwide. The search for new anti-T. drugs are relevant because only two exist actually. objective this study was to investigate effect extracts from seeds Lonchocarpus cultratus on T. cruzi, its cytotoxicity as well elucidate chemical profile.
 Methodology: characterization done u...

Abstract Chagas disease is a zoonosis caused by Trypanosoma cruzi and transmitted triatomine bugs. Autochthonous to Latin America, has spread globally through travel migration. New drugs are needed urgently, in particular that cure the chronic stage. This where high-content imaging makes key contribution: assays with fluorescent parasites cell culture allow determine pharmacodynamic parameters ...

In experimental murine infections with Trypanosoma rangeli it has been observed development immune response to Trypanosoma cruzi. The aim of the present work was to analyze the result of antigenic stimuli and the protective effect with T. rangeli in T. cruzi infections. Mice groups immunized with metacyclic trypomastigotes of T. rangeli (Choach -2V strain), derived from haemolymph and salivary ...

Trypanosomatidae is a group of protozoa belonging to Trypanosomatida order, where the genres of medical importance Leishmania and Trypanosoma are inserted. These genres include parasites Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei, etiologic agents of leishmaniasis, Chagas disease and sleeping sickness, respectively classified as Neglected Tropical Diseases (NTDs) by the World Hea...

Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, has infected 6 million people, putting 70 people at risk worldwide. Presently, very limited drugs are available, and these have severe side effects. Hence, there is an urgency to delve into other pathways targets for novel drugs. cruzi) expresses a number different cyclic AMP (cAMP)-specific phosphodiesterases (PDEs). cAMP one...