Tuberous sclerosis complex (TSC) is a genetic neurocutaneous condition, which affects multiple organ systems. This study aimed to determine the presenting features of children with TSC in Cape Town, South Africa. A cross-sectional study was conducted at a TSC clinic, and clinical features at presentation were prospectively collected. Thirty-nine children (23 boys; median age 10 (range 1 - 26) y...

Tuberous sclerosis complex (TSC) manifests predominantly as a neurocutaneous disorder. Lymphangioleiomyomatosis (LAM) is a rare pulmonary manifestation of TSC. Imaging evaluation plays an important role in the assessment of patients with tuberous sclerosis complex. In newly diagnosed patients, it helps not only to confirm the diagnosis of TSC, but also helps in identifying clinically significan...

BACKGROUND Skin manifestations of Tuberous Sclerosis Complex (TSC) cause significant morbidity. The molecular mechanism underlying TSC is understood and there is evidence that systemic treatment with rapamycin or other mTOR inhibitors may be a useful approach to targeted therapy for the kidney and brain manifestations. Here we investigate topical rapamycin in a mouse model for TSC-related tumor...

Tuberous sclerosis complex (TSC) is an autosomal dominant, variably expressed multisystem disease. The predominant pulmonary features of TSC are identical to those of lymphangioleiomyomatosis (LAM). Pneumothorax, multifocal micronodular pneumocyte hyperplasia, and chylothorax are rare complications of TSC. We report a young male with pneumothorax, lung nodules, and chylous effusion who develope...

We derive new bounds on the total squared correlation (TSC) of quaternary (quadriphase) signature/sequence sets for all lengths L and set sizes K. Then, for all K,L, we design minimum-TSC optimal sets that meet the new bounds with equality. Direct numerical comparison with the TSC value of the recently obtained optimal binary sets shows under what K,L realizations gains are materialized by movi...

Tuberous sclerosis (TSC) is a single-gene disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological (e.g., epilepsy), cognitive (intellectual disabilities, specific neuropsychological impairments) and behavioral pathologies (e.g., autism, attention deficit hyperactivity disorder). In addition, there is a high prevalence of psychiatric problems...

Feedback control of fluids is often achieved with limited state measurements. Effective approaches utilize compensators, which can be computed using linear quadratic Gaussian (LQG) or MinMax control designs. However, to achieve real-time control algorithms, these compensators must have low computational complexity. Model reduction methods are a natural choice to build reduced-order compensators...

PUP Compensator In this paper, we consider linear time-invariant multi-input multi-output (MIMO) systems that are stabilizable by proportionalintegral (PI) compensators. Such systems are also stabilizable by a PI-type compensator to be denoted by PIP. The P I P compensator consists of a PI compensator in the feedforward loop preceding the plant to be controlled, and a proportional gain in a fee...