Three thousand four hundred eighty-five BCG scar negative school children were given tuberculin test. Results showed very little non-specific reactions, suggesting BCG should produce high levels of protection in our population.

T HE TUBERCULIN TEST IS THE MOST effective means for detecting tuberculous infection, and hence is an essential tool in ultimate eradication of the disease. In clinical practice it has been generally accepted that a positive tuberculin skin reaction indicates the possibility of tuberculosis, whereas a negative reaction, with few exceptions, rules out a tuberculous infection. Since the advent of...

Background: Tuberculosis (TB) remains an important health problem throughout the world. Despite its significance in public health, mechanisms of protective immunity against Mycobacyerium Tuberculosis in humans have not yet been understood. Objective: To evaluate cell mediated immune response against purified Ag 85, PPD and Phytohemagglutinin (PHA) in patients with tuberculosis and healthy tuber...

The tuberculin for Mantoux-test is neither heated nor filtered after diluting, of course. Heating of a diluted tuberculin was once made half in fun. And as stated in section 3.1 and 6.1, a diluted tuberculin was sealed in ampuls, and heated by autoclaving for 20 minutes at 15 pounds pressure (120•Ž). After this precedure we saw a curious result: the potency was lost on the whole, of course, but...

BACKGROUND Repeat tuberculin skin tests may be false positive due to boosting of waned immunity to past mycobacterial exposure. We evaluated whether an ELISPOT test could identify tuberculosis (TB) contacts with boosting of immunity to non-tuberculous mycobacterial exposure. METHODOLOGY/PRINCIPAL FINDINGS We conducted tuberculin and ELISPOT tests in 1665 TB contacts: 799 were tuberculin test ...

The aim was to study the tuberculin skin test in relation to immunological in vitro reactions in bacille Calmette-Guerin (BCG)-vaccinated healthcare workers. The present study was performed in Sweden, a country with a low incidence of tuberculosis, a high BCG vaccination efficacy and high tuberculin conversion rates. BCG-vaccinated healthcare workers (n=381) were tuberculin skin tested. From th...