easily differentiated from the BY normal contour and color of the A. R. MASTEN, M.D. s]dn Specific because without wheatridge, Colo. a pl.ece(]jng infection with tubercle bacilli no reaction will occur. Accurate because no other known combination of factors will give the same result. That is, a person cannot become sensitive to tuberculin by any means except a previous infection with tubercle b...


 There is a lack of evidence on the clinical utility interferon gamma release assay for identifying latent tuberculosis infection in rural and remote settings.
 In Indigenous communities with known history bacillus Calmette-Guérin vaccination, more positive tests results were reported tuberculin skin test than assay.

The precise origin of cells infiltrating tuberculin skin reactions was studied with the technique of immunofluorescence. Thymectomized, irradiated Lewis rats were restored with bone marrow from allogeneic or F(1) donors. They were passively sensitized to tuberculin by a subsequent transfer of Lewis lymph node cells and were given intradermal skin tests with tuberculoprotein. In 24 hr reactions ...

A trial of tuberculosis vaccines in more than 54,000 adolescents, nearly all aged 14 to 5l years and attending school in urban or suburban areas, was started in England in 1950-2 (Medical Research Council, 1956, 1959, 1963). Those found to be tuberculin-negative on entry to the trial-that is, with no induration, or one of less than 5 mm., both to 3 and to 100 tuberculin units (T.U.) of Old Tube...

The heptapeptide Asn-Gly-Ser-Gln-Met-Arg-Leu, part of a tuberculin-active intracellular mycobacterial protein and described in the literature as having residual tuberculin activity, has been synthesized. Biological assays of the synthetic peptide showed it to be recognized as an antigen of mycobacterial origin by its ability to elicit an early allergic reaction in Mycobacterium bovis BCG-infect...

In 1937, the foundation year of the Brazilian Institute for Tuberculosis Research, three questions persisted in the researchers' mind: "What is the real value of BCG? How to solve the problem of the chest register of large communities? When will we have a specific drug for the treatment of tuberculosis?" Along with this line of thought, the author presents a list of the Institute's main contrib...

Cell mediated immunity was studied by a leucocyte migration inhibition assay and by tuberculin and dinitrochlorobenzene skin tests in 30 patients with recurrent genital warts and in 34 healthy people (with no history of genital warts) who served as controls. Migration inhibition was significantly less in patients suffering from recurrences for more than one year than in controls (p less than 0....