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BACKGROUND Leprosy is characterized histologically by a spectrum of different granulomatous skin lesions, reflecting patients' immune responses to Mycobacterium leprae. Although CD4+CD25+ FoxP3+ T regulatory cells are pivotal in the immuneregulation, presence, frequency, and distribution of Tregs in leprosy, its reactional states have been investigated in few studies. OBJECTIVES This study ai...

The clinical forms of leprosy constitute a spectrum that correlates closely with the degree of cell-mediated immunity. Patients with tuberculoid leprosy develop strong cell-mediated responses and have only a few, localized lesions, whereas patients with multibacillary lepromatous leprosy are specifically unresponsive to antigens of Myobacterium leprae. T cells of the CD4+ subset predominate in ...

This study illustrates the consequences of smallpox revaccination in 45 lepromatous, 28 tuberculoid, and 47 normal individuals. Results obtained with intradermal inoculations indicated that the patients with leprosy were associated with a relative anergy against the vaccinia virus, the anergy being minimal in the tuberculoid leprosy but marked in the cases with lepromatous leprosy. Major vaccin...

The three latest International Congresses of leprologists (Madrid 1953, Tokio 1958, Rio 1963) have recognised two polar types of leprosy, tuberculoid and lepromatous and one inter­ mediate group, borderline. These three categories faintly reflect the con­ cept of a spectrum of clinicai, immunological, bacteriological and histological signs. Apart from these categories a group of cases with inch...

Two groups, each of 1 00 patients suffering from tuberculoid leprosy, were treated with different dosages of dapsone, the control group being given a conservative dosage of the drug and the study group a high dosage ( 1 200 mg weekly) . The patients in the high-dosage group showed more rapid regression of the disease , a lower incidence of relapse and early regression of the tingling, enlargeme...