Goal: The potent anti-cancer activity of Arteether (ARE) has been the focus of many studies. However, the hydrophobic property of this drug limits its application. To increase the bioavailability of ARE, we formulated a nanosystem (NS) of folic acid (FA), chitosan (CS) and Fe3O4 for delivery of ARE against breast cancer. Material and Methods: The CS coated Fe3O4 was synthesized by co-precipitat...

Nanoparticle-based drug delivery systems allow improved solubility, enhanced stability in circulation and multi-functionality. These properties and functions open many doors and create new biomedical applications for targeting drugs or imaging agents directly to the disease site. Due to the high incidence and mortality of cancer, studies are concentrating on targeted drug delivery to the tumor....

despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...

Drug delivery for brain tumors is a questionable subject which is the major barrier in treatment. Nowadays, a lot of proposals have been developed to increase the amount of intravascular drug reaching the tumor. All drugs have a common disadvantage, only a small amount of delivered drug actually reaches the tumor. The systemic toxicity is the main doselimiting factor. When we are given directly...

In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, "stealth-like" doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like do...

Targeted drug delivery to tumor sites is one of the ultimate goals in drug delivery. Recent progress in nanoparticle engineering has certainly improved drug targeting, but the results are not as good as expected. This is largely due to the fact that nanoparticles, regardless of how advanced they are, find the target as a result of blood circulation, like the conventional drug delivery systems d...