OBJECTIVE We evaluated the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes. RESEARCH DESIGN AND METHODS We analyzed 14 SNPs at HHEX, CDKAL1, CDKN2B, SLC30A8, KCNJ11, IGF2BP2, PPARG, TCF7L2, FTO, KCNQ1, IRS-1, GCKR, UBE2E2, and C2CD4A/B in 1,487 Japanese individuals (724 patients with type 2 diabetes and 763 control subjects). A GRS w...

Diacylglycerol (DAG) is a lipid signal messenger and plays a physiological role in β-cells. Since defective glucose homeostasis increases de novo DAG synthesis, DAG may also contribute to β-cell dysfunction in type 2 diabetes. Although the primary function of DAG is to activate protein kinase C (PKC), the role of PKC in insulin secretion is controversial: PKC has been reported to act as both a ...

Proteins of the β-propeller fold are ubiquitous in nature and widely used as structural scaffolds for ligand binding and enzymatic activity. This fold comprises between four and twelve four-stranded β-meanders, the so called blades that are arranged circularly around a central funnel-shaped pore. Despite the large size range of β-propellers, their blades frequently show sequence similarity indi...

Objective: Pancreatic b-cell dysfunction is described to be present at the diagnosis of type 2 diabetes mellitus (T2DM) and progressively deteriorated with disease duration. However, its progression is variable and potentially influenced by several factors. The Magnesium (Mg) deficiency mediates insulin resistance but reports regarding its role in pancreatic β-cell dysfunction are scarce and co...

Abstract The melting and recrystallization behavior of -iPP crystal induced by β -nucleating agent was studied. A new type α-modification has been developed self-seeding process. growth process these crystals is just like “photographic development process.” Crystalline phase transformation the memory effect caused local order observed during annealing high temperature sufficient to destroy β-nu...

Baizhanov and Baldwin [1] introduce the notions of benign and weakly benign sets to investigate the preservation of stability by naming arbitrary subsets of a stable structure. They connect the notion with work of Baldwin, Benedikt, Bouscaren, Casanovas, Poizat, and Ziegler. Stimulated by [1], we investigate here the existence of benign or weakly benign sets. Definition 0.1 1. The set A is beni...

both anorganic bovine bone (abb) and β-tricalcium phosphate (β-tcp) are used in clinical practice as bone substitute materials, but there is limited data comparing these two materials in standardized defects. the aim of this study was to histologically evaluate the effectiveness of abb and β-tcp in the healing of experimentally induced bone defects.eighteen bone defects were created on the calv...

Le diabète de type 1 est associé à une dysbiose et perte d’intégrité intestinale qui apparaissent avant le diagnostic. Ces altérations sont liées inflammation intestinale, des traitements contre la et/ou l’inflammation améliorent fonction cellules β-pancréatiques. Type diabetes is associated with dysbiosis and loss of intestinal integrity that appear before disease onset. These alterations are ...

Baizhanov and Baldwin [1] introduce the notions of benign and weakly benign sets to investigate the preservation of stability by naming arbitrary subsets of a stable structure. They connect the notion with work of Baldwin, Benedikt, Bouscaren, Casanovas, Poizat, and Ziegler. Stimulated by [1], we investigate here the existence of benign or weakly benign sets. Definition 0.1 1. The set A is beni...

The lymphotoxin signaling pathway plays an important role in the homeostasis and function of peripheral and mucosal dendritic cells, and dendritic cell-intrinsic lymphotoxin β receptor expression is required for optimal responses to opportunistic intestinal bacteria. However, it is unknown whether dendritic cell-intrinsic lymphotoxin β receptor signaling is required for responses to intestinal ...