نتایج جستجو برای: unbound aggregate
تعداد نتایج: 49655 فیلتر نتایج به سال:
Unbound drug is the pharmacodynamically relevant concentration. This study aimed to determine if chronologic age or markers of biologic aging, such as the frailty phenotype and p16INK4a gene expression, altered unbound pharmacokinetics (PKs) of efavirenz (EFV) and atazanavir/ritonavir (ATV/RTV). Sixty human immunodeficiency virus (HIV)-infected participants receiving EFV and 31 receiving ATV/RT...
Here we report on the unexpected electrophoretic behavior of complexes between rod-like virus particles (virions) and bivalent antibodies. The multiple complexes formed by the virions and antibodies migrated with electrophoretic mobilities of much greater absolute values than those of the unbound virions or antibodies while typically complexes have mobilities intermediate to those of their comp...
We have characterized the interaction between apolipoprotein E (apoE) and amyloid beta peptide (Abeta) in the soluble fraction of the cerebral cortex of Alzheimer's disease (AD) and control subjects. Western blot analysis with specific antibodies identified in both groups a complex composed of the full-length apoE and Abeta peptides ending at residues 40 and 42. The apoE-Abeta soluble aggregate...
The unbound drug hypothesis states that only unbound drug concentrations are active and available for clearance, and highly variable results regarding unbound vancomycin fractions have been reported in the literature. We have determined the unbound vancomycin fractions in four different patient groups by a liquid chromatography tandem mass spectrometry (LC-MS/MS) method and identified factors t...
Till thine Infinity shall be A robe of envenomed agony; And thine Omnipotence a crown of pain, To cling like burning gold round thy dissolving brain. 1 Introduction 2 To the ω'th station! 3 Scope of some other models: the extent of computation in Malament-Hogarth spacetimes. Case Studies: a) Etesi-Németi models in Kerr spacetimes; b) Hogarth's models more abstractly considered.
A variational principle is constructed for gravity coupled to an asymptotically linear dilaton and a p-form field strength. This requires the introduction of appropriate surface terms – also known as ‘boundary counterterms’ – in the action. The variation of the action with respect to the boundary metric yields a boundary stress tensor, which is used to construct conserved charges that generate ...
Etoposide protein binding in cancer patients is variable and has been related mathematically to a linear model consisting of serum albumin and total bilirubin [percentage unbound = (1.4 x total bilirubin) - (6.8 x albumin) + 34.4]. In this prospective evaluation of the model, plasma samples were obtained following the administration of etoposide in 31 patients, and the unbound percentage (% unb...
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