Development and preclinical evaluation of therapies for spinal muscular atrophy A. Burghes , K. Foust , V. McGovern , P. Poresnsky , A. Bevan , S. Duque , T. Le , C. Iyer , A. Laporte , I. Alwin , C. Mitrpant , S. Wilton , B. Kaspar b Ohio State University, Molecular and Cellular Biochemistry, Columbus, OH, United States; Nation Wide Children’s Hospital, Gene Therapy Center, Columbus, OH, Unite...

Climate has a primary influence on the occurrence and rate of combustion in ecosystems with carbon-based fuels such as forests and grasslands. Society will be confronted with the effects of climate change on fire in future forests. There are, however, few quantitative appraisals of how climate will affect wildland fire in the United States. We demonstrated a method for estimating changes in fir...

First posted July 27, 2021 For additional information, contact: Water Resources Mission AreaU.S. Geological Survey12201 Sunrise Valley DriveReston, VA 20192Contact Pubs Warehouse The United States faces growing challenges to its water supply, infrastructure, and aquatic ecosystems because of population growth, climate change, floods, droughts. To help address these challenges, the U.S. Survey A...

In the aftermaths of both World War I and World War II, the United States engaged in significant domestic political debates over its proper place in the world. President Wilson’s brainchild, the League of Nations, was the centerpiece of the first debate, and the United Nations the centerpiece of the second. The conventional wisdom is that the dark forces of isolationism defeated Wilson’s League...

INTRODUCTION Two recent articles (both published in Psychological Science) rely on nation-level data to address questions about psychological processes: Oishi and Diener (2014), referred to here as “OD,” and Hershfield et al. (2014), referred to as “HBW.” In our opinion, both articles contain problems with regard to the use and interpretation of nation-level data. The problems are (1) the failu...

On March 3, 2013 the National Academy of Sciences will be 150 years old. Its creation in 1863 represents part of a dramatic series of federal actions that positioned the United States of America for a bright future. In 1862, Congress passed and President Lincoln signed the Morrill Act, creating Land Grant Colleges, providing federal land grants for the use of the new colleges and allowing the l...