نتایج جستجو برای: urate deposition
تعداد نتایج: 96523 فیلتر نتایج به سال:
Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS...
We report a case of a 34-year-old man who had an acute gouty attack with tophi around the accessory bone of the bipartite patella with intra-osseous lesions. As the symptoms did not respond to conservative treatments, the patient was treated surgically. Arthroscopy revealed urate crystals surrounded by inflammatory synovitis on the surface of the bipartite patella. Arthrotomy exposed the abunda...
Gout is a form of arthritis with a documented history spanning several thousands of years. Observed by the ancient Egyptian medical practitioner Imhotep as early as 2640BCE, it was also described several centuries later by the Greek physician Hippocrates (400BCE), the father of modern medicine, who referred to it as podagra, or “the unwalkable disease”. Gout represents the most frequent inflamm...
Gouty panniculitis is a rare cutaneous illness characterized by the deposition of subcutaneous mono-sodium urate crystals with lobular panniculitis. Only a small number of cases with gouty panniculitis have been reported in the literature with unclear pathogenesis. In this article, we present a case of disseminated gouty panniculitis in the patient who had never been diagnosed of gout but revea...
OBJECTIVES To determine whether hypouricaemic treatment results in the disappearance of urate crystals from gouty joints and to define the time required. METHODS In 18 patients with monosodium urate (MSU) crystal proven gout, and after the initiation of successful serum uric acid (SUA)-lowering treatment, an arthrocentesis of the asymptomatic signal joint (11 knees, 7 first metatarsophalangea...
Gout is a metabolic disorder that usually presents as recurrent episodes of acute arthritis due to deposition of crystals in joints and cartilages. Despite the availability of several drugs for gout, its management is still less than adequate. There is always a search for newer, safer, and more potent urate-lowering therapies for treating patients inadequately controlled with available drugs. L...
A total of 60, 3-week-old, laying pullets were used in the present experiment. The exposed birds received excess sodium bicarbonate (SB) in their drinking water for 35 days at the levels of: 2 g/l (0.2%), 7.5 g/l (0.75%), 20 g/l (2%) and 40 g/l (4%). All birds were subjected to pathological and toxicological examination. Birds of the 0.75% and 2%-groups developed gross picture of visceral gout,...
The natural history of gout typically consists of three periods in a continuum: asymptomatic hyperuricaemia, episodes of acute attacks of gout with asymptomatic intervals, and chronic gouty arthritis. The last decade has seen major advances in our knowledge of acute attacks of gout with the discovery of the pivotal role of interleukin 1 (IL-1); however, the mechanisms that trigger acute flares ...
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