Serotonin is believed as an important factor in brain function. The role of serotonin in cerebral psycho-patho-physiology has already been well established. However, the function of serotonin antagonist in anesthetized subjects under hyperthermia has not been studied properly. Methods: Experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control group, (ii) wh...

Responses of many neurons in primary visual cortex (V1) are suppressed by stimuli exceeding the classical receptive field (RF), an important property that might underlie the computation of visual saliency. Traditionally, it has proven difficult to disentangle the underlying neural circuits, including feedforward, horizontal intracortical, and feedback connectivity. Since circuit-level analysis ...

Hippocampal oscillations recorded under urethane anesthesia are proposed to be modulated by anxiolytics. All classes of clinically effective anxiolytics were reported to decrease the frequency of urethane theta; however, recent findings raise concerns about the direct correlation of anxiolysis and the frequency of hippocampal theta. Here, we took advantage of our two inbred mouse strains displa...

BACKGROUND Mice that have defects in their low-threshold T-type calcium channel (T-channel) genes show altered pain behaviors. The changes in the ratio of nociceptive neurons and the burst firing property of reticular thalamic (RT) and ventroposterior (VP) neurons in Cav3.2 knockout (KO) mice were studied to test the involvement of thalamic T-channel and burst firing activity in pain function. ...

Prof. Dr. M. Hohenegger, Laxenburgerstrasse 39, A-1100 Vienna (Austria) Dear Sir, Previous investigations in rats 24 and 48 h after nephrectomy revealed normal or even increased cardiac output and arterial blood pressure, normal arterial and tissue oxygen partial pressures, and decreased PaC02 [1]. The whole body oxygen consumption was depressed by about 40 and 60%, respectively, whereas BUN wa...

Previous work has demonstrated an influence of the respiratory cycle and, more specifically, rhythmic nasal inspiration for the entrainment of slow oscillations in olfactory cortex during ketamine-xylazine anesthesia. This respiratory entrainment has been suggested to occur more broadly during slow-wave states (including sleep) throughout the forebrain, in particular in the frontal and parahipp...

We studied cellular mechanisms of synchronization of epileptiform activity induced by kainic acid in a novel preparation of superfused rat hippocampus in vivo. Under urethane anesthesia, kainate induced epileptic population spikes occurring at 30-40 Hz. Pyramidal cells fired exclusively during population spikes with an average probability of 0.34 on rebound of rhythmic GABA(A)-mediated inhibito...

BACKGROUND Serotonin is believed as an important factor in brain function. The role of serotonin in cerebral psycho-patho-physiology has already been well established. However, the function of serotonin antagonist in anesthetized subjects under hyperthermia has not been studied properly. METHODS Experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control gro...