PURPOSE To evaluate the value of contrast-enhanced ultrasonography (CEUS) in the differentiation of high and low grade urothelial carcinoma. MATERIALS AND METHODS 192 with 192 bladder lesions, including 110 high grade urothelial carcinoma and 82 low grade urothelial carcinoma were examined by CEUS. Among 192 tumors, enhancement patterns of 96 tumors between August 2010 and December 2012 were ...

Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on a set of human tumors of this type and identified a phosphatidylinositol 3-kinase (PI3K)/AKT activation expression signature in 76.9% (n = 13) of our samples. Sequence analysis found both activating mutations of PIK3CA (13.6%, n = 22) and loss of heterozy...

INTRODUCTION A primary ureteral stump tumor after a nephrectomy is rare; urothelial carcinoma of the ureteral stump after a nephrectomy for renal cell carcinoma is even rarer. A thorough review of the literature indicated that only seven cases have previously been reported. In this study, we report the first Taiwanese case of urothelial carcinoma of the ureteral stump after a nephrectomy. It is...

UNLABELLED It has been 12 yr since the publication of the last World Health Organization (WHO) classification of tumours of the prostate and bladder. During this time, significant new knowledge has been generated about the pathology and genetics of these tumours. Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 WHO classification. In most cases, it represents intra...

BACKGROUND Extracellular vesicles are lipid bilayer vesicles containing protein, messengerRNA and microRNA. Cancer cell-derived extracellular vesicles may be diagnostic and therapeutic targets. We extracted extracellular vesicles from urine of urothelial carcinoma patients and the control group to identify cancer-specific microRNAs in urinary extracellular vesicles as new biomarkers. MATERIAL...

OBJECTIVES Urothelial carcinoma of the bladder occurs rarely in the first 2 decades of life. We report a case of a 12 year-old child that presented with a Ta grade II/III urothelial carcinoma of the bladder. METHODS We describe its clinical presentation and diagnostic procedures as well as treatment and follow-up. Finally, we review the literature to analyze the etiology, treatment, and surve...

BACKGROUND To investigate the clinical manifestation, diagnosis, treatment, and outcome of simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma. METHODS Twenty-seven consecutive patients with synchronous renal cell carcinoma and urothelial carcinoma treated in two tertiary medical centers from March 2005 to December 2015 were retrospectively reviewed. Their clinical,...

Urothelial carcinoma is a heterogeneous tumor with great propensity for divergent differentiation resulting in an urothelial carcinoma admixed with other morphologically recognizable components. [1] The most common mixed differentiation is squamous followed by glandular. [1-5] The whole spectrum of bladder carcinoma variants may be seen in variable proportion from an otherwise typical urothelia...

Malignant epithelial tumors presenting within the hernia sacs are rare, occurring in 0.14% of all surgically removed adult hernia sac cases [1]. Most reports document inguinal or umbilical hernia sac with metastatic adenocarcinoma from multiple organs [1-4]. To the best of our knowledge, no cases of ventral hernia sac with metastatic urothelial carcinoma have been previously reported. We herein...