Thin-plate V-notch weirs are commonly used as measuring devices in flumes and channels. Herein, the discharge calibration of a large 90o V-notch weir was performed using an unsteady volume per time technique. The weir overflow was initially shut. The sudden opening of the gate was associated with an initial phase of transient water motion associated with a negative wave propagating in the reser...

The light weight of magnesium alloys makes them a promising material in different potential industries, such as aerospace and automobile. In addition, are attractive materials for biomedical applications due to their biocompatibility with the human body. these structural parts require an understanding fatigue behavior because they usually subjected time-varying loading. Furthermore, notches ine...

in this paper, the mean value of strain energy density criterion has been used to predict the critical fracture load in specimens with u-shaped notch under bending loads. an equation for calculation of averaged strain energy density in this zone has been presented. bending loads under mode i have been considered. two cases have been studied: 1) the control volume only includes the semicircular ...

Evaluation of the morphology of the suprascapular notch region is important from a clinical point of view because it is the most common site of suprascapular nerve compression and injury. A group of 120 patients underwent ultrasound examination of the suprascapular notch region according to our original four-stage "step-by-step" protocol. The notches were classified based on their morphology an...

BACKGROUND We have been investigating how interruption of differentiation contributes to the oncogenic process and the possibility to reverse the transformed phenotype by restoring differentiation. In a previous report, we correlated the capacity of intracellular Notch (ICN) to suppress v-Src-mediated transformation of quail neuroretina (QNR/v-src(ts)) cells with the acquisition by these undiff...

The acquisition of endocrine therapy resistance in estrogen receptor α (ERα) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine therapy. Following activation, Notch intracellular domain is released and enters the nucleus where activates transcription of target genes. Th...

In this paper, the influence of notch depth-to-width ratios on J-integral and critical load of Aluminium 8011 alloy specimens with U-notch under Mode I loading are studied. Using experiments, for a set of specimens having different notch depth–to–width ratios, J-integral was found and the same was verified using analytical methods. Further, using the results obtained from the experiments, failu...

in this paper, the experimental method of caustics and its application to stress field and related studies in fracture mechanics is described. theocaris [1,2,3] has used the optical method of caustics to study stress intensity factors and the stress field around crack tips, in cracked transparent plates. many other researchers have also used this method to obtain stress intensity factors for di...