The syndrome of vacuous chewing movements (VCMs) in rats is similar in many respects to tardive dyskinesia (TD) in humans. Both syndromes are characterized by delayed onset of persistent orofacial dyskinesias in a sub-group of subjects chronically treated with neuroleptics. Using the rat model, we examined the role of NMDA receptor-mediated corticostriatal neurotransmission in the expression of...

To explore associations of neostriatal (NST) endogenous levels of dopamine (DA) and serotonin (5-HT) with sensitivity of their receptors, graded doses of 6-hydroxydopamine HBr (0 to 400 micrograms, ICV; 6-OHDA; desipramine pretreatment, 20 mg/kg IP) were given to rats between birth (P 0) and P 42. Numbers of vacuous chewing movements (VCMs) induced by SKF 38393 or m-chlorophenylpiperazine (m-CP...

This report describes a different approach for diminishing the movements of orbital prosthesis during mimic movements and chewing function. Mechanical devices such as magnets are used to enhance the retention in case lack of the implants. However rigid fixation of obturator and orbital prosthesis can result in movements of the orbital prosthesis during mastication. In this case obturator and or...

Tardive Dyskinesia (TD) is a severe movement disorder of the orofacial region caused by the typical neuroleptic, haloperidol. It was reported that haloperidol-induced TD is mediated through oxidative stress mechanism which is triggered by calcium overload. Moreover, the disturbance of melatonin secretion due to pineal gland calcification is linked to the pathophysiology of TD. Therefore, the ai...

The aim of the present study was to assess the effect of a denture adhesive (DA) on patient satisfaction and kinesiographic parameters of complete denture wearers by a cross-over study. Fifty edentulous patients received a set of new complete dentures. After an adaptation period, the participants were enrolled in the trial and randomized to receive a sequence of treatment protocols: Protocol 1-...

The treatment of animals with neuroleptic drugs for periods of a few results in the induction of dopamine (DA) receptor supersensitivity that is reflected, on drugwithdrawal, by enhanced behavioural responses to DA agonist drugs (Muller and Seeman, 1978). Such phenomena have been considered to exemplify the pathophysiology of tardive dyskinesia (Baldessarini and Tarsy, 1980) despite the require...